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dc.contributor.author | Fernández de las Peñas, César | |
dc.contributor.author | Martín Guerrero, José D. | |
dc.contributor.author | Pellicer Valero, Óscar J. | |
dc.contributor.author | Navarro Pardo, Esperanza | |
dc.contributor.author | Gómez Mayordomo, Víctor | |
dc.contributor.author | Cuadrado, María L. | |
dc.contributor.author | Arias Navalón, José Antonio![]() |
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dc.contributor.author | Cigarán Méndez, Margarita | |
dc.contributor.author | Hernández Barrera, Valentín | |
dc.contributor.author | Arendt Nielsen, Lars | |
dc.date.accessioned | 2022-01-25T13:30:38Z | |
dc.date.available | 2022-01-25T13:30:38Z | |
dc.date.created | 2022-01-14 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12080/29144 | |
dc.description.abstract | This multicenter cohort study investigated the differences between coronavirus disease 2019 (COVID-19) related symptoms and post-COVID symptoms between male and female COVID-19 survivors. Clinical and hospitalization data were collected from hospital medical records in a sample of individuals recovered from COVID-19 at five public hospitals in Spain. A predefined list of post-COVID symptoms was systematically assessed, but patients were free to report any symptom. Anxiety/depressive levels and sleep quality were also assessed. Adjusted multivariate logistic regressions were used to identify the association of sex with post-COVID related-symptoms. A total of 1969 individuals (age: 61, SD: 16 years, 46.4% women) were assessed 8.4 months after discharge. No overall significant sex differences in COVID-19 onset symptoms at hospital admission were found. Post-COVID symptoms were present in up to 60% of hospitalized COVID-19 survivors eight months after the infection. The number of post-COVID symptoms was 2.25 for females and 1.5 for males. After adjusting by all variables, female sex was associated with ¿3 post-COVID symptoms (adj OR 2.54, 95%CI 1.671¿3.865, p < 0.001), the presence of post-COVID fatigue (adj OR 1.514, 95%CI 1.040¿2.205), dyspnea (rest: adj OR 1.428, 95%CI 1.081¿1.886, exertion: adj OR 1.409, 95%CI 1.109¿1.791), pain (adj OR 1.349, 95%CI 1.059¿1.720), hair loss (adj OR 4.529, 95%CI 2.784¿7.368), ocular problems (adj OR 1.981, 95%CI 1.185¿3.312), depressive levels (adj OR 1.606, 95%CI 1.002¿2.572) and worse sleep quality (adj OR 1.634, 95%CI 1.097¿2.434). Female sex was a risk factor for the development of some long-term post-COVID symptoms including mood disorders. Healthcare systems should consider sex differences in the management of long haulers. Keywords: COVID-19; sex; female; symptoms; fatigue; post-COVID; risk factors | es_ES |
dc.format | application/pdf | es_ES |
dc.language | eng | es_ES |
dc.rights | CC-BY | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.es | es_ES |
dc.title | Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.location | N/A | es_ES |