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Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients

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Valle Millares, Daniel & Brochado Kith, Óscar & Martín Carbonero, Luz & Domínguez Domínguez, Lourdes & Ryan, Pablo & De los Santos, Ignacio & De la Fuente, Sara & Castro, Juan M. & Lagarde, María & Cuevas, Guillermo & Mayoral Muñoz, Mario & Matarranz, Mariano & Díez, Victorino & Gómez Sanz, Alicia & Martínez Román, Paula & Crespo Bermejo, Celia & Palladino, Claudia & Muñoz Muñoz, María & Jiménez Sousa, María A. & Resino, Salvador & Briz, Verónica & Fernández Rodríguez, Amanda .Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients.

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Valle Millares, Daniel & Brochado Kith, Óscar & Martín Carbonero, Luz & Domínguez Domínguez, Lourdes & Ryan, Pablo & De los Santos, Ignacio & De la Fuente, Sara & Castro, Juan M. & Lagarde, María & Cuevas, Guillermo & Mayoral Muñoz, Mario & Matarranz, Mariano & Díez, Victorino & Gómez Sanz, Alicia & Martínez Román, Paula & Crespo Bermejo, Celia & Palladino, Claudia & Muñoz Muñoz, María & Jiménez Sousa, María A. & Resino, Salvador & Briz, Verónica & Fernández Rodríguez, Amanda. Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients.

https://hdl.handle.net/20.500.12080/26278
dc.contributor.author Valle Millares, Daniel
dc.contributor.author Brochado Kith, Óscar
dc.contributor.author Martín Carbonero, Luz
dc.contributor.author Domínguez Domínguez, Lourdes
dc.contributor.author Ryan, Pablo
dc.contributor.author De los Santos, Ignacio
dc.contributor.author De la Fuente, Sara
dc.contributor.author Castro, Juan M.
dc.contributor.author Lagarde, María
dc.contributor.author Cuevas, Guillermo
dc.contributor.author Mayoral Muñoz, Mario
dc.contributor.author Matarranz, Mariano
dc.contributor.author Díez, Victorino
dc.contributor.author Gómez Sanz, Alicia
dc.contributor.author Martínez Román, Paula
dc.contributor.author Crespo Bermejo, Celia
dc.contributor.author Palladino, Claudia
dc.contributor.author Muñoz Muñoz, María
dc.contributor.author Jiménez Sousa, María A.
dc.contributor.author Resino, Salvador
dc.contributor.author Briz, Verónica
dc.contributor.author Fernández Rodríguez, Amanda
dc.date.accessioned 2021-11-30T13:24:44Z
dc.date.available 2021-11-30T13:24:44Z
dc.date.created 2021-11-05
dc.identifier.uri https://hdl.handle.net/20.500.12080/26278
dc.description.abstract Micro RNAs (miRNAs) are essential players in HIV and HCV infections, as both viruses modulate cellular miRNAs and interact with the miRNA-mediated host response. We aim to analyze the miRNA profile of HIV patients with different exposure to HCV to explore specific signatures in the miRNA profile of PBMCs for each type of infection. We massively sequenced small RNAs of PBMCs from 117 HIV+ infected patients: 45 HIV+ patients chronically infected with HCV (HIV/HCV+), 36 HIV+ that spontaneously clarified HCV after acute infection (HIV/HCV-) and 36 HIV+ patients without previous HCV infection (HIV). Thirty-two healthy patients were used as healthy controls (HC). Differential expression analysis showed significantly differentially expressed (SDE) miRNAs in HIV/HCV+ (n = 153), HIV/HCV- (n = 169) and HIV (n = 153) patients. We found putative dysregulated pathways, such as infectious-related and PI3K signaling pathways, common in all contrasts. Specifically, putatively targeted genes involved in antifolate resistance (HIV/HV+), cancerrelated pathways (HIV/HCV-) and HIF-signaling (HIV) were identified, among others. Our findings revealed that HCV strongly influences the expression profile of PBMCs from HIV patients through the disruption of its miRNome. Thus, different HCV exposure can be identified by specific miRNA signatures in PBMCs. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.subject HCV; HIV; microRNAs; spontaneous viral clearance; high throughput sequence es_ES
dc.title Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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