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dc.contributor.author | López Escobar, Alejandro | |
dc.contributor.author | Velazquez, Sara | |
dc.contributor.author | Madurga, Rodrigo | |
dc.contributor.author | Castellano, José María | |
dc.contributor.author | Rodriguez Pascual, Jesús | |
dc.contributor.author | Ruiz de Aguiar Diaz Obregon, Santiago | |
dc.contributor.author | Jimeno, Sara | |
dc.contributor.author | Montero, Juan Ignacio | |
dc.contributor.author | Ventura Wichner, Paula Sol | |
dc.date.accessioned | 2024-10-30T11:36:32Z | |
dc.date.available | 2024-10-30T11:36:32Z | |
dc.date.created | 2021 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12080/44692 | |
dc.description.abstract | Background The vast impact of COVID-19 call for the identification of clinical parameter that can help predict a torpid evolution. Among these, endothelial injury has been proposed as one of the main pathophysiological mechanisms underlying the disease, promoting a hyperinflammatory and prothrombotic state leading to worse clinical outcomes. Leukocytes and platelets play a key role in inflammation and thrombogenesis, hence the objective of the current study was to study whether neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII) as well as the new parameter neutrophil-to-platelet ratio (NPR), could help identify patients who at risk of admission at Intensive Care Units. Methods A retrospective observational study was performed at HM Hospitales including electronic health records from 2245 patients admitted due to COVID-19 from March 1 to June 10, 2020. Patients were divided into two groups, admitted at ICU or not. Results Patients who were admitted at the ICU had significantly higher values in all hemogram-derived ratios at the moment of hospital admission compared to those who did not need ICU admission. Specifically, we found significant differences in NLR (6.9 [4¿11.7] vs 4.1 [2.6¿7.6], p¿<¿ 0.0001), PLR (2 [1.4¿3.3] vs 1.9 [1.3¿2.9], p¿=¿0.023), NPR (3 [2.1¿4.2] vs 2.3 [1.6¿3.2], p¿<¿ 0.0001) and SII (13 [6.5¿25.7] vs 9 [4.9¿17.5], p¿<¿ 0.0001) compared to those who did not require ICU admission. After multivariable logistic regression models, NPR was the hemogram-derived ratio with the highest predictive value of ICU admission, (OR 1.11 (95% CI: 0.98¿1.22, p¿=¿0.055). Conclusions Simple, hemogram-derived ratios obtained from early hemogram at hospital admission, especially the novelty NPR, have shown to be useful predictors of risk of ICU admission in patients hospitalized due to COVID-19. | es_ES |
dc.format | application/pdf | es_ES |
dc.language | eng | es_ES |
dc.rights | CC-BY | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.es | es_ES |
dc.source | BMC Emergency Medicine | es_ES |
dc.title | Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.location | N/A | es_ES |