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Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19

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López Escobar, Alejandro & Velazquez, Sara & Madurga, Rodrigo & Castellano, José María & Rodriguez Pascual, Jesús & Ruiz de Aguiar Diaz Obregon, Santiago & Jimeno, Sara & Montero, Juan Ignacio & Ventura Wichner, Paula Sol .Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19.

ISO 690

López Escobar, Alejandro & Velazquez, Sara & Madurga, Rodrigo & Castellano, José María & Rodriguez Pascual, Jesús & Ruiz de Aguiar Diaz Obregon, Santiago & Jimeno, Sara & Montero, Juan Ignacio & Ventura Wichner, Paula Sol. Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19.

https://hdl.handle.net/20.500.12080/44692
dc.contributor.author López Escobar, Alejandro
dc.contributor.author Velazquez, Sara
dc.contributor.author Madurga, Rodrigo
dc.contributor.author Castellano, José María
dc.contributor.author Rodriguez Pascual, Jesús
dc.contributor.author Ruiz de Aguiar Diaz Obregon, Santiago
dc.contributor.author Jimeno, Sara
dc.contributor.author Montero, Juan Ignacio
dc.contributor.author Ventura Wichner, Paula Sol
dc.date.accessioned 2024-10-30T11:36:32Z
dc.date.available 2024-10-30T11:36:32Z
dc.date.created 2021
dc.identifier.uri https://hdl.handle.net/20.500.12080/44692
dc.description.abstract Background The vast impact of COVID-19 call for the identification of clinical parameter that can help predict a torpid evolution. Among these, endothelial injury has been proposed as one of the main pathophysiological mechanisms underlying the disease, promoting a hyperinflammatory and prothrombotic state leading to worse clinical outcomes. Leukocytes and platelets play a key role in inflammation and thrombogenesis, hence the objective of the current study was to study whether neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII) as well as the new parameter neutrophil-to-platelet ratio (NPR), could help identify patients who at risk of admission at Intensive Care Units. Methods A retrospective observational study was performed at HM Hospitales including electronic health records from 2245 patients admitted due to COVID-19 from March 1 to June 10, 2020. Patients were divided into two groups, admitted at ICU or not. Results Patients who were admitted at the ICU had significantly higher values in all hemogram-derived ratios at the moment of hospital admission compared to those who did not need ICU admission. Specifically, we found significant differences in NLR (6.9 [4¿11.7] vs 4.1 [2.6¿7.6], p¿<¿ 0.0001), PLR (2 [1.4¿3.3] vs 1.9 [1.3¿2.9], p¿=¿0.023), NPR (3 [2.1¿4.2] vs 2.3 [1.6¿3.2], p¿<¿ 0.0001) and SII (13 [6.5¿25.7] vs 9 [4.9¿17.5], p¿<¿ 0.0001) compared to those who did not require ICU admission. After multivariable logistic regression models, NPR was the hemogram-derived ratio with the highest predictive value of ICU admission, (OR 1.11 (95% CI: 0.98¿1.22, p¿=¿0.055). Conclusions Simple, hemogram-derived ratios obtained from early hemogram at hospital admission, especially the novelty NPR, have shown to be useful predictors of risk of ICU admission in patients hospitalized due to COVID-19. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.source BMC Emergency Medicine es_ES
dc.title Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19 es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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