APA
López Escobar, Alejandro & Velazquez, Sara & Madurga, Rodrigo & Castellano, José María & Rodriguez Pascual, Jesús & Ruiz de Aguiar Diaz Obregon, Santiago & Jimeno, Sara & Montero, Juan Ignacio & Ventura Wichner, Paula Sol .Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19.
ISO 690
López Escobar, Alejandro & Velazquez, Sara & Madurga, Rodrigo & Castellano, José María & Rodriguez Pascual, Jesús & Ruiz de Aguiar Diaz Obregon, Santiago & Jimeno, Sara & Montero, Juan Ignacio & Ventura Wichner, Paula Sol. Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19.
https://hdl.handle.net/20.500.12080/44692
dc.contributor.author |
López Escobar, Alejandro |
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dc.contributor.author |
Velazquez, Sara |
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dc.contributor.author |
Madurga, Rodrigo |
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dc.contributor.author |
Castellano, José María |
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dc.contributor.author |
Rodriguez Pascual, Jesús |
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dc.contributor.author |
Ruiz de Aguiar Diaz Obregon, Santiago |
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dc.contributor.author |
Jimeno, Sara |
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dc.contributor.author |
Montero, Juan Ignacio |
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dc.contributor.author |
Ventura Wichner, Paula Sol |
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dc.date.accessioned |
2024-10-30T11:36:32Z |
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dc.date.available |
2024-10-30T11:36:32Z |
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dc.date.created |
2021 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12080/44692 |
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dc.description.abstract |
Background
The vast impact of COVID-19 call for the identification of clinical parameter that can help predict a torpid evolution. Among these, endothelial injury has been proposed as one of the main pathophysiological mechanisms underlying the disease, promoting a hyperinflammatory and prothrombotic state leading to worse clinical outcomes. Leukocytes and platelets play a key role in inflammation and thrombogenesis, hence the objective of the current study was to study whether neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII) as well as the new parameter neutrophil-to-platelet ratio (NPR), could help identify patients who at risk of admission at Intensive Care Units.
Methods
A retrospective observational study was performed at HM Hospitales including electronic health records from 2245 patients admitted due to COVID-19 from March 1 to June 10, 2020. Patients were divided into two groups, admitted at ICU or not.
Results
Patients who were admitted at the ICU had significantly higher values in all hemogram-derived ratios at the moment of hospital admission compared to those who did not need ICU admission. Specifically, we found significant differences in NLR (6.9 [4¿11.7] vs 4.1 [2.6¿7.6], p¿<¿ 0.0001), PLR (2 [1.4¿3.3] vs 1.9 [1.3¿2.9], p¿=¿0.023), NPR (3 [2.1¿4.2] vs 2.3 [1.6¿3.2], p¿<¿ 0.0001) and SII (13 [6.5¿25.7] vs 9 [4.9¿17.5], p¿<¿ 0.0001) compared to those who did not require ICU admission. After multivariable logistic regression models, NPR was the hemogram-derived ratio with the highest predictive value of ICU admission, (OR 1.11 (95% CI: 0.98¿1.22, p¿=¿0.055).
Conclusions
Simple, hemogram-derived ratios obtained from early hemogram at hospital admission, especially the novelty NPR, have shown to be useful predictors of risk of ICU admission in patients hospitalized due to COVID-19. |
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dc.format |
application/pdf |
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dc.language |
eng |
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dc.rights |
CC-BY |
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dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/deed.es |
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dc.source |
BMC Emergency Medicine |
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dc.title |
Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19 |
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dc.type |
info:eu-repo/semantics/article |
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dc.rights.accessrights |
info:eu-repo/semantics/openAccess |
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dc.identifier.location |
N/A |
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