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Clinical characteristics and outcomes of 1,331 patients with COVID-19: HM Spanish Cohort

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Cardinal-Fernández, Pablo & Garcia Cuesta, Esteban & Barberán, José & Varona, José F. & Estirado, Alberto & Moreno, Alberto & Villanueva, Julio & Villareal, Mercedes & Baez-Pravia, Orville & Menéndez, Justo & Villares, Paula & López Escobar, Alejandro & Rodríguez-Pascual, Jesús & Almirall, Cristina & Domínguez, Eduardo & Pey, Carlos & Ferreiro, Antonio & Revilla Amores, Manuel & Sánchez, Nike & Ruiz de Aguiar, Santiago & Castellano, José M. .Clinical characteristics and outcomes of 1,331 patients with COVID-19: HM Spanish Cohort.

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Cardinal-Fernández, Pablo & Garcia Cuesta, Esteban & Barberán, José & Varona, José F. & Estirado, Alberto & Moreno, Alberto & Villanueva, Julio & Villareal, Mercedes & Baez-Pravia, Orville & Menéndez, Justo & Villares, Paula & López Escobar, Alejandro & Rodríguez-Pascual, Jesús & Almirall, Cristina & Domínguez, Eduardo & Pey, Carlos & Ferreiro, Antonio & Revilla Amores, Manuel & Sánchez, Nike & Ruiz de Aguiar, Santiago & Castellano, José M.. Clinical characteristics and outcomes of 1,331 patients with COVID-19: HM Spanish Cohort.

https://hdl.handle.net/20.500.12080/44656
dc.contributor.author Cardinal-Fernández, Pablo
dc.contributor.author Garcia Cuesta, Esteban
dc.contributor.author Barberán, José
dc.contributor.author Varona, José F.
dc.contributor.author Estirado, Alberto
dc.contributor.author Moreno, Alberto
dc.contributor.author Villanueva, Julio
dc.contributor.author Villareal, Mercedes
dc.contributor.author Baez-Pravia, Orville
dc.contributor.author Menéndez, Justo
dc.contributor.author Villares, Paula
dc.contributor.author López Escobar, Alejandro
dc.contributor.author Rodríguez-Pascual, Jesús
dc.contributor.author Almirall, Cristina
dc.contributor.author Domínguez, Eduardo
dc.contributor.author Pey, Carlos
dc.contributor.author Ferreiro, Antonio
dc.contributor.author Revilla Amores, Manuel
dc.contributor.author Sánchez, Nike
dc.contributor.author Ruiz de Aguiar, Santiago
dc.contributor.author Castellano, José M.
dc.date.accessioned 2024-10-21T14:20:20Z
dc.date.available 2024-10-21T14:20:20Z
dc.date.created 2021
dc.identifier.uri https://hdl.handle.net/20.500.12080/44656
dc.description.abstract Background. Spain is one of the European countries most affected by the COVID-19 pandemic. Epidemiologic studies are warranted to improve the disease understanding, evaluate the care procedure and prepare for futures waves. The aim of the study was to describe epidemiologic characteristics associated with hospitalized patients with COVID-19. Methods. This real-world, observational, multicenter and retrospective study screened all consecutive patients admitted to 8 Spanish private hospitals. Inclusion criteria: hospitalized adults (age¿18 years old) with clinically and radiologically findings compatible with COVID-19 disease from March 1st to April 5th, 2020. Exclusion criteria: patients presenting negative PCR for SARS-CoV-2 during the first 7 days from hospital admission, transfer to a hospital not belonging to the HM consortium, lack of data and discharge against medical advice in emergency departments. Results. One thousand and three hundred thirty-one COVID-19 patients (medium age 66.9 years old; males n= 841, medium length of hospital stayed 8 days, non-survivors n=233) were analyzed. One hundred and fifteen were admitted to intensive care unit (medium length of stay 16 days, invasive mechanical ventilation n= 95, septic shock n= 37 and renal replacement therapy n= 17). Age, male gender, leukocytes, platelets, oxygen saturation, chronic therapy with steroids and treatment with hydroxychloroquine/azithromycin were independent factors associated with mortality. The proportion of patients that survive and received tocilizumab and steroids were lesser and higher respectively than those that die, but their association was not significant. Conclusions. Overall crude mortality rate was 17.5%, rising up to 36.5% in the subgroup of patients that were admitted to the intensive care unit. Seven factors impact in hospital mortality. No immunomodulatory intervention were associated with in-hospital mortality. Keywords: SARS-CoV-2; COVID-19; pandemic; epidemiology es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.source Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia es_ES
dc.subject SARS-CoV-2; COVID-19; pandemic; epidemiology es_ES
dc.title Clinical characteristics and outcomes of 1,331 patients with COVID-19: HM Spanish Cohort es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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