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Bisphenol S is a haemodialysis-associated xenobiotic that is less toxic than bisphenol A

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Mas, Sebastian & Ruiz Priego, Alberto & Abaigar, Pedro & Santos, Javier & Camarero, Vanesa & Egido, Jesús & Ortiz, Alberto & Gonzalez Parra, Emilio (2021 ) .Bisphenol S is a haemodialysis-associated xenobiotic that is less toxic than bisphenol A.

ISO 690

Mas, Sebastian & Ruiz Priego, Alberto & Abaigar, Pedro & Santos, Javier & Camarero, Vanesa & Egido, Jesús & Ortiz, Alberto & Gonzalez Parra, Emilio. 2021 .Bisphenol S is a haemodialysis-associated xenobiotic that is less toxic than bisphenol A.

https://hdl.handle.net/20.500.12080/39742
dc.contributor.author Mas, Sebastian
dc.contributor.author Ruiz Priego, Alberto
dc.contributor.author Abaigar, Pedro
dc.contributor.author Santos, Javier
dc.contributor.author Camarero, Vanesa
dc.contributor.author Egido, Jesús
dc.contributor.author Ortiz, Alberto
dc.contributor.author Gonzalez Parra, Emilio
dc.date.accessioned 2024-02-12T15:28:47Z
dc.date.available 2024-02-12T15:28:47Z
dc.date.created 2021
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12080/39742
dc.description.abstract Background. Bisphenol S (BPS) is a structural analogue of bisphenol A (BPA) that is found in the environment. BPS may accumulate in anuric patients due to decreased urinary excretion. The toxicity and health effects of BPS are poorly characterized. Methods. A cross-over study was performed using polynephron (PN) or polysulphone (PS) dialysers for a short (1 week each, 14 patients) or long (3 months each, 20 patients) period on each dialyser. Plasma BPA, BPS and hippuric acid were assessed by SRM mass spectrometry (SRM-MS). The biological significance of the BPS concentrations found was explored in cultured kidney tubular cells. Results. In haemodiafiltration (HDF) patients, plasma BPS was 10-fold higher than in healthy subjects (0.53 6 0.52 versus 0.05 6 0.01 ng/mL; P¼ 0.0015), while BPA levels were 35-fold higher (13.23 6 14.65 versus 0.37 6 0.12 ng/mL; P¼ 0.007). Plasma hippuric acid decreased after an HDF session, while BPS and BPA did not. After 3 months of HDF with the same membranes, the BPS concentration was 1.01 6 0.87 ng/mL for PN users and 0.62 6 0.21 ng/mL for PS users (P non-statistically significant). In vitro, BPS and BPA leaked from dialysers containing them. In cultured tubular cells, no biological impact (cytotoxicity, inflammatory and oxidative stress gene expression) was observed for BPS up to 200 mM, while BPA was toxic at concentrations 100 mM. Conclusions. BPS may be released from dialysis membranes, and dialysis patients display high BPS concentrations. However, BPS concentrations are lower than BPA concentrations and no BPS toxicity was observed at concentrations found in patient plasma. Keywords: bisphenol A, bisphenol S, chronic kidney disease, haemodialysis, haemodiafiltration, toxins, xenobiotics es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Bisphenol S is a haemodialysis-associated xenobiotic that is less toxic than bisphenol A es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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