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Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

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Opazo Ríos, Lucas & Mas, Sebastian & Marín Royo, Gema & Mezzano, Sergio & Gómez Guerrero, Carmen & Moreno, Juan Antonio & Egido, Jesús (2020 ) .Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.

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Opazo Ríos, Lucas & Mas, Sebastian & Marín Royo, Gema & Mezzano, Sergio & Gómez Guerrero, Carmen & Moreno, Juan Antonio & Egido, Jesús. 2020 .Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.

https://hdl.handle.net/20.500.12080/39740
dc.contributor.author Opazo Ríos, Lucas
dc.contributor.author Mas, Sebastian
dc.contributor.author Marín Royo, Gema
dc.contributor.author Mezzano, Sergio
dc.contributor.author Gómez Guerrero, Carmen
dc.contributor.author Moreno, Juan Antonio
dc.contributor.author Egido, Jesús
dc.date.accessioned 2024-02-12T15:26:36Z
dc.date.available 2024-02-12T15:26:36Z
dc.date.created 2020
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12080/39740
dc.description.abstract Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas, skeletal muscle, liver, and kidney. Serum lipid abnormalities and renal ectopic lipid accumulation have been associated with the development of kidney diseases, in particular diabetic nephropathy. Chronic hyperinsulinemia, often seen in type 2 diabetes, plays a crucial role in blood and liver lipid metabolism abnormalities, thus resulting in increased non-esterified fatty acids (NEFA). Excessive lipid accumulation alters cellular homeostasis and activates lipogenic and glycogenic cell-signaling pathways. Recent evidences indicate that both quantity and quality of lipids are involved in renal damage associated to lipotoxicity by activating inflammation, oxidative stress, mitochondrial dysfunction, and cell-death. The pathological effects of lipotoxicity have been observed in renal cells, thus promoting podocyte injury, tubular damage, mesangial proliferation, endothelial activation, and formation of macrophage-derived foam cells. Therefore, this review examines the recent preclinical and clinical research about the potentially harmful effects of lipids in the kidney, metabolic markers associated with these mechanisms, major signaling pathways affected, the causes of excessive lipid accumulation, and the types of lipids involved, as well as offers a comprehensive update of therapeutic strategies targeting lipotoxicity. Keywords: lipotoxicity; obesity; type 2 diabetes; fatty kidney; diabetic nephropathy; chronic kidney disease es_ES
dc.format application/pdf es_ES
dc.language hun es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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