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Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice

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Sastre, Cristina & Rubio Navarro, Alfonso & Buendía, Irene & Gómez Guerrero, Carmen & Blanco, Julia & Mas, Sebastian & Egido, Jesús & Blanco Colio, Luis Miguel & Ortiz, Alberto & Moreno, Juan Antonio (2013-12 ) .Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice.

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Sastre, Cristina & Rubio Navarro, Alfonso & Buendía, Irene & Gómez Guerrero, Carmen & Blanco, Julia & Mas, Sebastian & Egido, Jesús & Blanco Colio, Luis Miguel & Ortiz, Alberto & Moreno, Juan Antonio. 2013-12 .Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice.

https://hdl.handle.net/20.500.12080/39737
dc.contributor.author Sastre, Cristina
dc.contributor.author Rubio Navarro, Alfonso
dc.contributor.author Buendía, Irene
dc.contributor.author Gómez Guerrero, Carmen
dc.contributor.author Blanco, Julia
dc.contributor.author Mas, Sebastian
dc.contributor.author Egido, Jesús
dc.contributor.author Blanco Colio, Luis Miguel
dc.contributor.author Ortiz, Alberto
dc.contributor.author Moreno, Juan Antonio
dc.date.accessioned 2024-02-12T15:23:33Z
dc.date.available 2024-02-12T15:23:33Z
dc.date.created 2013-12
dc.date.issued 2013-12
dc.identifier.uri https://hdl.handle.net/20.500.12080/39737
dc.description.abstract Background: Klotho is a renal protein with anti-aging properties that is downregulated in conditions related to kidney injury. Hyperlipidemia accelerates the progression of renal damage, but the mechanisms of the deleterious effects of hyperlipidemia remain unclear. Methods: We evaluated whether hyperlipidemia modulates Klotho expression in kidneys from C57BL/6 and hyperlipidemic apolipoprotein E knockout (ApoE KO) mice fed with a normal chow diet (ND) or a Western-type high cholesterol-fat diet (HC) for 5 to 10 weeks, respectively. Results: In ApoE KO mice, the HC diet increased serum and renal cholesterol levels, kidney injury severity, kidney macrophage infiltration and inflammatory chemokine expression. A significant reduction in Klotho mRNA and protein expression was observed in kidneys from hypercholesteromic ApoE KO mice fed a HC diet as compared with controls, both at 5 and 10 weeks. In order to study the mechanism involved in Klotho down-regulation, murine tubular epithelial cells were treated with ox-LDL. Oxidized-LDL were effectively uptaken by tubular cells and decreased both Klotho mRNA and protein expression in a time- and dose-dependent manner in these cells. Finally, NF-kB and ERK inhibitors prevented ox-LDL induced Klotho downregulation. Conclusion: Our results suggest that hyperlipidemia-associated kidney injury decreases renal expression of Klotho. Therefore, Klotho could be a key element explaining the relationship between hyperlipidemia and aging with renal disease es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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