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Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes

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Mas, Sebastian & Martínez Pinna, Roxana & Martín Ventura, Jose Luis & Pérez, Raul & Gomez Garre, Dulcenombre & Ortiz, Alberto & Fernandez Cruz, Arturo & Vivanco, Fernando & Egido, Jesús (2010-06 ) .Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes.

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Mas, Sebastian & Martínez Pinna, Roxana & Martín Ventura, Jose Luis & Pérez, Raul & Gomez Garre, Dulcenombre & Ortiz, Alberto & Fernandez Cruz, Arturo & Vivanco, Fernando & Egido, Jesús. 2010-06 .Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes.

https://hdl.handle.net/20.500.12080/39713
dc.contributor.author Mas, Sebastian
dc.contributor.author Martínez Pinna, Roxana
dc.contributor.author Martín Ventura, Jose Luis
dc.contributor.author Pérez, Raul
dc.contributor.author Gomez Garre, Dulcenombre
dc.contributor.author Ortiz, Alberto
dc.contributor.author Fernandez Cruz, Arturo
dc.contributor.author Vivanco, Fernando
dc.contributor.author Egido, Jesús
dc.date.accessioned 2024-02-12T11:27:12Z
dc.date.available 2024-02-12T11:27:12Z
dc.date.created 2010-06
dc.date.issued 2010-06
dc.identifier.uri https://hdl.handle.net/20.500.12080/39713
dc.description.abstract OBJECTIVE¿Atherosclerosis is prevalent in diabetic patients, but there is little information on the localization of nonesterified fatty acids (NEFAs) within the plaque and their relationship with inflammation. We sought to characterize the NEFA composition and location in human diabetic atheroma plaques by metabolo mic analysis and imaging and to address their relationship with inflammation activity. RESEARCH DESIGN AND METHODS¿Time-of-flight sec ondary ion mass spectrometry (TOF-SIMS) was used for metabo lomic analysis imaging of frozen carotid atheroma plaques. Carotid endarterectomy specimens were used for conventional immunohistochemistry, laser-capture microdissection quantita tive PCR, and in situ Southwestern hybridization. Biological actions of linoleic acid were studied in cultured vascular smooth muscle cells (VSMCs). RESULTS¿TOF-SIMS imaging evidenced a significant increase in the quantity of several NEFA in diabetic versus nondiabetic atheroma plaques. Higher levels of NEFA were also found in diabetic sera. The presence of LPL mRNA in NEFA-rich areas of the atheroma plaque, as well as the lack of correlation between serum and plaque NEFA, suggests a local origin for plaque NEFA. The pattern of distribution of plaque NEFA is similar to that of MCP-1, LPL, and activated NF- B. Diabetic endarterectomy specimens showed higher numbers of infiltrating macrophages and T-lymphocytes¿a finding that associated with higher NEFA levels. Finally, linoleic acid activates NF- B and upregulates NF- B¿mediated LPL and MCP-1 expression in cultured VSMC. DISCUSSION¿There is an increased presence of NEFA in diabetic plaque neointima. NEFA levels are higher in diabetic atheroma plaques than in nondiabetic subjects. We hypothesize that NEFA may be produced locally and contribute to local inflammation es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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