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Mouse Model of Microembolic Stroke and Reperfusion

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APA

Atochin, D.N. & Murciano, Juan Carlos & Gursoy-Özdemir, Y. & Krasik, T. & Noda, F. & Ayata, C. & Dunn, A.K. & Moskowitz, M.A. & Huang, P.L. & Muzykantov, V.R. (2004 ) .Mouse Model of Microembolic Stroke and Reperfusion.

ISO 690

Atochin, D.N. & Murciano, Juan Carlos & Gursoy-Özdemir, Y. & Krasik, T. & Noda, F. & Ayata, C. & Dunn, A.K. & Moskowitz, M.A. & Huang, P.L. & Muzykantov, V.R.. 2004 .Mouse Model of Microembolic Stroke and Reperfusion.

https://hdl.handle.net/20.500.12080/39707
dc.contributor.author Atochin, D.N.
dc.contributor.author Murciano, Juan Carlos
dc.contributor.author Gursoy-Özdemir, Y.
dc.contributor.author Krasik, T.
dc.contributor.author Noda, F.
dc.contributor.author Ayata, C.
dc.contributor.author Dunn, A.K.
dc.contributor.author Moskowitz, M.A.
dc.contributor.author Huang, P.L.
dc.contributor.author Muzykantov, V.R.
dc.date.accessioned 2024-02-12T10:33:30Z
dc.date.available 2024-02-12T10:33:30Z
dc.date.created 2004
dc.date.issued 2004
dc.identifier.uri https://hdl.handle.net/20.500.12080/39707
dc.description.abstract Background and Purpose¿To test the role of fibrinolysis in stroke, we used a mouse model in which preformed 2.5- to 3- m-diameter fibrin microemboli are injected into the cerebral circulation. The microemboli lodge in the downstream precapillary vasculature and are susceptible to fibrinolysis. Methods¿We injected various doses of microemboli into the internal carotid artery in mice and characterized their distribution, effects on cerebral blood flow, neurological deficit, infarct area, and spontaneous dissolution. By comparing wild-type and tissue plasminogen activator (tPA) knockout (tPA / ) mice, we analyzed the role of endogenous tPA in acute thrombotic stroke. Results¿Microemboli cause dose-dependent brain injury. Although moderate doses of microemboli are followed by spontaneous reperfusion, they result in reproducible injury. Gene knockout of tPA markedly delays dissolution of cerebral emboli and restoration of blood flow and aggravates ischemic thrombotic infarction in the brain. Conclusions¿We describe a microembolic model of stroke, in which degree of injury can be controlled by the dose of microemboli injected. Unlike vessel occlusion models, this model can be modulated to allow spontaneous fibrinolysis. Application to tPA / mice supports a key role of endogenous tPA in restoring cerebral blood flow and limiting infarct size after thrombosis. (Stroke. 2004;35:2177-2182.) Key Words: animal models fibrinolysis microemboli stroke stroke, embolic es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Mouse Model of Microembolic Stroke and Reperfusion es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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