Repositorio Institucional de la Universidad Alfonso X el Sabio

Biliopancreatic cancer is one of the most aggressive solid neoplasms, and incidence is rising worldwide. It is known that ATF6¿ is one of the transmembrane proteins that acts crucially in endoplasmic reticulum stress response, and knockdown induces apoptosis of pancreatic cells. Apart from this, p-p38 has been previously correlated with better outcome in pancreatic cancer. Interestingly, ATF6¿ knockdown pancreatic cells showed increased p-p38. The aim of this study was to evaluate the expression of these 2 proteins, p-p38 and ATF6¿, and their correlation with the outcome of biliopancreatic adenocarcinoma patients. Samples from patients with biliopancreatic adenocarcinoma that underwent pancreaticoduodenectomy from 2007 to 2013 were used to construct a tissue microarray to evaluate p-p38 and ATF6¿ proteins by immunohistochemistry. We observed that both markers showed a tendency to impact in the time to recurrence; then a combination of these 2 proteins was analyzed. Combination of ATF6¿(high) and p-p38(low) was strongly associated with a higher risk of recurrence (hazard ratio 2.918, P = 0.013). This 2-protein model remained significant after multivariate adjustment.We proposed a 2-protein signature based on ATF6¿(high) and p-p38(low) as a potential biomarker of risk of recurrence in resected biliopancreatic adenocarcinoma patients.

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Javier Martinez-Useros1*, Tihomir Georgiev-Hristov2, MarõÂa JesuÂs FernaÂndez-Aceñero3, Aurea Borrero-Palacios1, Alberto Indacochea4,5, Santiago Guerrero4,6, Weiyao Li1, Arancha CebriaÂn1, Teresa GoÂmez del Pulgar1, Alberto Puime-Otin7, Laura del Puerto- Nevado1, MarõÂa RodrõÂguez-RemõÂrez1, Nuria PeÂrez7, Angel CeldraÂn8, FaÂtima Gebauer4,6, Jesus Garcia-Foncillas1* & Martinez-Useros, Javier & Georgiev-Hristov, Tihomir & Fernandez-Aceñero, Maria J. & Borrero-Palacios, Aurea & Indacocheas, Ignacio & Et al. (2017 ) .Biliopancreatic cancer is one of the most aggressive solid neoplasms, and incidence is rising worldwide. It is known that ATF6¿ is one of the transmembrane proteins that acts crucially in endoplasmic reticulum stress response, and knockdown induces apoptosis of pancreatic cells. Apart from this, p-p38 has been previously correlated with better outcome in pancreatic cancer. Interestingly, ATF6¿ knockdown pancreatic cells showed increased p-p38. The aim of this study was to evaluate the expression of these 2 proteins, p-p38 and ATF6¿, and their correlation with the outcome of biliopancreatic adenocarcinoma patients. Samples from patients with biliopancreatic adenocarcinoma that underwent pancreaticoduodenectomy from 2007 to 2013 were used to construct a tissue microarray to evaluate p-p38 and ATF6¿ proteins by immunohistochemistry. We observed that both markers showed a tendency to impact in the time to recurrence; then a combination of these 2 proteins was analyzed. Combination of ATF6¿(high) and p-p38(low) was strongly associated with a higher risk of recurrence (hazard ratio 2.918, P = 0.013). This 2-protein model remained significant after multivariate adjustment.We proposed a 2-protein signature based on ATF6¿(high) and p-p38(low) as a potential biomarker of risk of recurrence in resected biliopancreatic adenocarcinoma patients..

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Javier Martinez-Useros1*, Tihomir Georgiev-Hristov2, MarõÂa JesuÂs FernaÂndez-Aceñero3, Aurea Borrero-Palacios1, Alberto Indacochea4,5, Santiago Guerrero4,6, Weiyao Li1, Arancha CebriaÂn1, Teresa GoÂmez del Pulgar1, Alberto Puime-Otin7, Laura del Puerto- Nevado1, MarõÂa RodrõÂguez-RemõÂrez1, Nuria PeÂrez7, Angel CeldraÂn8, FaÂtima Gebauer4,6, Jesus Garcia-Foncillas1* & Martinez-Useros, Javier & Georgiev-Hristov, Tihomir & Fernandez-Aceñero, Maria J. & Borrero-Palacios, Aurea & Indacocheas, Ignacio & Et al.. 2017 .Biliopancreatic cancer is one of the most aggressive solid neoplasms, and incidence is rising worldwide. It is known that ATF6¿ is one of the transmembrane proteins that acts crucially in endoplasmic reticulum stress response, and knockdown induces apoptosis of pancreatic cells. Apart from this, p-p38 has been previously correlated with better outcome in pancreatic cancer. Interestingly, ATF6¿ knockdown pancreatic cells showed increased p-p38. The aim of this study was to evaluate the expression of these 2 proteins, p-p38 and ATF6¿, and their correlation with the outcome of biliopancreatic adenocarcinoma patients. Samples from patients with biliopancreatic adenocarcinoma that underwent pancreaticoduodenectomy from 2007 to 2013 were used to construct a tissue microarray to evaluate p-p38 and ATF6¿ proteins by immunohistochemistry. We observed that both markers showed a tendency to impact in the time to recurrence; then a combination of these 2 proteins was analyzed. Combination of ATF6¿(high) and p-p38(low) was strongly associated with a higher risk of recurrence (hazard ratio 2.918, P = 0.013). This 2-protein model remained significant after multivariate adjustment.We proposed a 2-protein signature based on ATF6¿(high) and p-p38(low) as a potential biomarker of risk of recurrence in resected biliopancreatic adenocarcinoma patients..

https://hdl.handle.net/20.500.12080/39676
dc.contributor.author Javier Martinez-Useros1*, Tihomir Georgiev-Hristov2, MarõÂa JesuÂs FernaÂndez-Aceñero3, Aurea Borrero-Palacios1, Alberto Indacochea4,5, Santiago Guerrero4,6, Weiyao Li1, Arancha CebriaÂn1, Teresa GoÂmez del Pulgar1, Alberto Puime-Otin7, Laura del Puerto- Nevado1, MarõÂa RodrõÂguez-RemõÂrez1, Nuria PeÂrez7, Angel CeldraÂn8, FaÂtima Gebauer4,6, Jesus Garcia-Foncillas1*
dc.contributor.author Martinez-Useros, Javier
dc.contributor.author Georgiev-Hristov, Tihomir
dc.contributor.author Fernandez-Aceñero, Maria J.
dc.contributor.author Borrero-Palacios, Aurea
dc.contributor.author Indacocheas, Ignacio
dc.contributor.author Et al.
dc.date.accessioned 2024-02-10T18:54:54Z
dc.date.available 2024-02-10T18:54:54Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12080/39676
dc.description.abstract Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient is a candidate for surgery. There are clinical guidelines for the management of these patients that offer different treatment options depending on the clinical and pathologic characteristics. However, the survival rates seen in this kind of patients are still low. The CDSE1 gene is located upstream of NRAS and encodes an RNA-binding protein termed UNR. The aim of this study was to analyze UNR expression and its correlation with outcome in patients with resectable pancreatic ductal adenocarcinoma (PDAC). For this, samples from resectable PDAC patients who underwent duodenopancreatectomy were used to evaluate UNR protein expression by immunohistochemistry using a tissue microarray. Here, we observed that low UNR expression was significantly associated with shorter progression-free survival after surgery (P = 0.010). Moreover, this prognostic marker remained significant after Cox proportional hazards model (P = 0.036). We further studied the role of CDSE1 expression in patient's prognosis using data from public repositories (GEO and TGCA), confirming our results. Interestingly, CDSE1 expression correlated with that of genes characteristic of an immunogenic molecular subtype of pancreatic cancer. Based on these findings, UNR may be considered a potential prognostic biomarker for resectable PDAC and may serve to guide subsequent adjuvant treatment decisions. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.source Plos One es_ES
dc.title Biliopancreatic cancer is one of the most aggressive solid neoplasms, and incidence is rising worldwide. It is known that ATF6¿ is one of the transmembrane proteins that acts crucially in endoplasmic reticulum stress response, and knockdown induces apoptosis of pancreatic cells. Apart from this, p-p38 has been previously correlated with better outcome in pancreatic cancer. Interestingly, ATF6¿ knockdown pancreatic cells showed increased p-p38. The aim of this study was to evaluate the expression of these 2 proteins, p-p38 and ATF6¿, and their correlation with the outcome of biliopancreatic adenocarcinoma patients. Samples from patients with biliopancreatic adenocarcinoma that underwent pancreaticoduodenectomy from 2007 to 2013 were used to construct a tissue microarray to evaluate p-p38 and ATF6¿ proteins by immunohistochemistry. We observed that both markers showed a tendency to impact in the time to recurrence; then a combination of these 2 proteins was analyzed. Combination of ATF6¿(high) and p-p38(low) was strongly associated with a higher risk of recurrence (hazard ratio 2.918, P = 0.013). This 2-protein model remained significant after multivariate adjustment.We proposed a 2-protein signature based on ATF6¿(high) and p-p38(low) as a potential biomarker of risk of recurrence in resected biliopancreatic adenocarcinoma patients. es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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