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Epidemiology, oncologic results and risk stratifcation model for metachronous peritoneal metastases after surgery for pT4 colon cancers: results from an observational retrospective multicentre long¿term follow¿up study

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Estaire Gómez, Mercedes & Cerdán¿Santacruz, C.  & Cano Valderrama, Ó.  &  Peña Ros, E. & Serrano del Moral, Á.  & Pereira Pérez, F.  &  Flor Lorente, B. & Biondo, S.  & Collaborating group for the study of metachronous peritoneal metastases of pT4 colon cancer (2023-05 ) .Epidemiology, oncologic results and risk stratifcation model for metachronous peritoneal metastases after surgery for pT4 colon cancers: results from an observational retrospective multicentre long¿term follow¿up study.

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Estaire Gómez, Mercedes & Cerdán¿Santacruz, C.  & Cano Valderrama, Ó.  &  Peña Ros, E. & Serrano del Moral, Á.  & Pereira Pérez, F.  &  Flor Lorente, B. & Biondo, S.  & Collaborating group for the study of metachronous peritoneal metastases of pT4 colon cancer. 2023-05 .Epidemiology, oncologic results and risk stratifcation model for metachronous peritoneal metastases after surgery for pT4 colon cancers: results from an observational retrospective multicentre long¿term follow¿up study.

https://hdl.handle.net/20.500.12080/39624
dc.contributor.author Estaire Gómez, Mercedes
dc.contributor.author Cerdán¿Santacruz, C. 
dc.contributor.author Cano Valderrama, Ó. 
dc.contributor.author  Peña Ros, E.
dc.contributor.author Serrano del Moral, Á. 
dc.contributor.author Pereira Pérez, F. 
dc.contributor.author  Flor Lorente, B.
dc.contributor.author Biondo, S. 
dc.contributor.author Collaborating group for the study of metachronous peritoneal metastases of pT4 colon cancer
dc.date.accessioned 2024-02-09T08:42:20Z
dc.date.available 2024-02-09T08:42:20Z
dc.date.created 2023-05
dc.date.issued 2023-05
dc.identifier.uri https://hdl.handle.net/20.500.12080/39624
dc.description.abstract Purpose Metachronous peritoneal metastases (MPM) following a curative surgery procedure for pT4 colon cancer is a chal lenging condition. Current epidemiological studies on this topic are scarce. Methods A retrospective multicentre trial was designed. All consecutive patients who underwent operations to treat pT4 cancers between 2015 and 2017 were reviewed. Demographic, clinical, operative, pathological and oncological follow-up variables were included. MPM were described as any oncological disease at the peritoneum, clearly diferent from a local recurrence. Univariate and multivariate Cox regression models were constructed. A risk stratifcation model was created on a cumulative factor basis. According to the calculated hazard ratio (HR), a scoring system was designed (HR<3, 1 point; HR>3, 2 points) and a scale from 0 to 6 was calculated for peritoneal disease-free rate (PDF-R). A risk stratifcation model was also created on the basis of these calculations. Results Fifty diferent hospitals were involved, which included a total of 1356 patients. Incidence of MPM was 13.6% at 50 months median follow-up. The strongest independent risk factors for MPM were positive pN stage [HR 3.72 (95% CI 2.56¿5.41; p<0.01) for stage III disease], tumour perforation [HR 1.91 (95% CI 1.26¿2.87; p<0.01)], mucinous or signet ring cell histology [HR 1.68 (95% CI 1.1¿2.58; p=0.02)], poorly diferentiated tumours [HR 1.54 (95% CI 1.1¿2.2; p=0.02)] and emergency surgery [HR 1.42 (95% CI 1.01¿2.01; p=0.049)]. In the absence of additional risk factors, pT4 tumours showed 98% and 96% PDF-R in 1-year and 5-year periods based on Kaplan¿Meier curves. Conclusions Cumulative MPM incidence was 13.6% at 5-year follow-up. The sole presence of a pT4 tumour resulted in high rates of PDF-R at 1-year and 5-year follow-up (98% and 96% respectively). Five additional risk factors diferent from pT4 status itself were identifed as possible MPM indicators during follow-up. Keywords Colon cancer · Metachronous peritoneal metastases · Second look · HIPEC · Risk stratifcation es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Epidemiology, oncologic results and risk stratifcation model for metachronous peritoneal metastases after surgery for pT4 colon cancers: results from an observational retrospective multicentre long¿term follow¿up study es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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