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Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

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APA

Peña Jimenez, Daniel & Fontenete, Silvia & Megias, Diego & Fustero Torre, Coral & Graña Castro, Osvaldo & Castellana, Donatello & Loewe, Robert & Perez Moreno, Mirna (2019 ) .Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.

ISO 690

Peña Jimenez, Daniel & Fontenete, Silvia & Megias, Diego & Fustero Torre, Coral & Graña Castro, Osvaldo & Castellana, Donatello & Loewe, Robert & Perez Moreno, Mirna. 2019 .Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.

https://hdl.handle.net/20.500.12080/39620
dc.contributor.author Peña Jimenez, Daniel
dc.contributor.author Fontenete, Silvia
dc.contributor.author Megias, Diego
dc.contributor.author Fustero Torre, Coral
dc.contributor.author Graña Castro, Osvaldo
dc.contributor.author Castellana, Donatello
dc.contributor.author Loewe, Robert
dc.contributor.author Perez Moreno, Mirna
dc.date.accessioned 2024-02-09T07:57:39Z
dc.date.available 2024-02-09T07:57:39Z
dc.date.created 2019
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12080/39620
dc.description.abstract Lymphatic vessels are essential for skin fluid homeostasis and immune cell trafficking. Whether the lymphatic vasculature is associated with hair follicle regeneration is, however, unknown. Here, using steady and live imaging approaches in mouse skin, we show that lymphatic vessels distribute to the anterior permanent region of individual hair follicles, starting from development through all cycle stages and interconnecting neighboring follicles at the bulge level, in a stem cell-depen dent manner. Lymphatic vessels further connect hair follicles in triads and dynamically flow across the skin. At the onset of the physiological stem cell activation, or upon pharmacological or genetic induction of hair follicle growth, lymphatic vessels transiently expand their caliber suggesting an increased tissue drainage capacity. Interestingly, the physiological caliber increase is associated with a distinct gene expression correlated with lymphatic vessel reorganization. Using mouse genetics, we show that lymphatic vessel depletion blocks hair follicle growth. Our findings point toward the lymphatic vasculature being important for hair follicle development, cycling, and organiza tion, and define lymphatic vessels as stem cell niche compo nents, coordinating connections at tissue-level, thus provide insight into their functional contribution to skin regeneration. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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