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Leon, Gonzalo & Sanchez Ruiloba, Lucia & Perez Rodriguez, Andrea & Gragera Alía, Teresa & Martinez, Natalia & Hernandez, Silvia & Anta, Berta & Calero, Olga & Garcia Dominguez, Carlota A. & Dura, Lara M. & Peña Jimenez, Daniel & Castro, Judit & Zarich, Natasha & Sanchez Gomez, Pilar & Calero, Miguel & Iglesias, Teresa & Oliva, Jose L. & Rojas, Jose M. (2014-12 ) .Shoc2/Sur8 Protein Regulates Neurite Outgrowth.

ISO 690

Leon, Gonzalo & Sanchez Ruiloba, Lucia & Perez Rodriguez, Andrea & Gragera Alía, Teresa & Martinez, Natalia & Hernandez, Silvia & Anta, Berta & Calero, Olga & Garcia Dominguez, Carlota A. & Dura, Lara M. & Peña Jimenez, Daniel & Castro, Judit & Zarich, Natasha & Sanchez Gomez, Pilar & Calero, Miguel & Iglesias, Teresa & Oliva, Jose L. & Rojas, Jose M.. 2014-12 .Shoc2/Sur8 Protein Regulates Neurite Outgrowth.

https://hdl.handle.net/20.500.12080/39616
dc.contributor.author Leon, Gonzalo
dc.contributor.author Sanchez Ruiloba, Lucia
dc.contributor.author Perez Rodriguez, Andrea
dc.contributor.author Gragera Alía, Teresa
dc.contributor.author Martinez, Natalia
dc.contributor.author Hernandez, Silvia
dc.contributor.author Anta, Berta
dc.contributor.author Calero, Olga
dc.contributor.author Garcia Dominguez, Carlota A.
dc.contributor.author Dura, Lara M.
dc.contributor.author Peña Jimenez, Daniel
dc.contributor.author Castro, Judit
dc.contributor.author Zarich, Natasha
dc.contributor.author Sanchez Gomez, Pilar
dc.contributor.author Calero, Miguel
dc.contributor.author Iglesias, Teresa
dc.contributor.author Oliva, Jose L.
dc.contributor.author Rojas, Jose M.
dc.date.accessioned 2024-02-08T17:11:30Z
dc.date.available 2024-02-08T17:11:30Z
dc.date.created 2014-12
dc.date.issued 2014-12
dc.identifier.uri https://hdl.handle.net/20.500.12080/39616
dc.description.abstract The Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited ERK activation. We demonstrate that ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of EGF, a stimulus that induces proliferation rather than differentiation in these cells. Finally, Shoc2 depletion reduces both NGF-induced neurite outgrowth and ERK activation in PC12 cells. Our data indicate that Shoc2 is essential to modulate the Ras-ERK signaling outcome in cell differentiation processes involved in neurite outgrowth. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Shoc2/Sur8 Protein Regulates Neurite Outgrowth es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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