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PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes

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APA

Anta, B & Pérez Rodríguez, A & Castro, J & García Domínguez, CA & Ibiza, S & Martínez, N & Durá, LM & Hernández, S & Gragera, T & Peña Jimenez, Daniel & Yunta González, Mónica & Zarich, N & Crespo, P & Serrador, JM & Santos, E & Muñoz, A & Oliva, JL & Rojas Cabañeros, José María (2016-07 ) .PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes.

ISO 690

Anta, B & Pérez Rodríguez, A & Castro, J & García Domínguez, CA & Ibiza, S & Martínez, N & Durá, LM & Hernández, S & Gragera, T & Peña Jimenez, Daniel & Yunta González, Mónica & Zarich, N & Crespo, P & Serrador, JM & Santos, E & Muñoz, A & Oliva, JL & Rojas Cabañeros, José María. 2016-07 .PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes.

https://hdl.handle.net/20.500.12080/39615
dc.contributor.author Anta, B
dc.contributor.author Pérez Rodríguez, A
dc.contributor.author Castro, J
dc.contributor.author García Domínguez, CA
dc.contributor.author Ibiza, S
dc.contributor.author Martínez, N
dc.contributor.author Durá, LM
dc.contributor.author Hernández, S
dc.contributor.author Gragera, T
dc.contributor.author Peña Jimenez, Daniel
dc.contributor.author Yunta González, Mónica
dc.contributor.author Zarich, N
dc.contributor.author Crespo, P
dc.contributor.author Serrador, JM
dc.contributor.author Santos, E
dc.contributor.author Muñoz, A
dc.contributor.author Oliva, JL
dc.contributor.author Rojas Cabañeros, José María
dc.date.accessioned 2024-02-08T17:01:31Z
dc.date.available 2024-02-08T17:01:31Z
dc.date.created 2016-07
dc.date.issued 2016-07
dc.identifier.uri https://hdl.handle.net/20.500.12080/39615
dc.description.abstract The cyclopentenone prostaglandin A1 (PGA1) is an inducer of cell death in cancer cells. However, the mechanism that initiates this cytotoxic response remains elusive. Here we report that PGA1 triggers apoptosis by a process that entails the specific activation of H- and N-Ras isoforms, leading to caspase activation. Cells without H- and N-Ras did not undergo apoptosis upon PGA1 treatment; in these cells, the cellular demise was rescued by overexpression of either H-Ras or N-Ras. Consistently, the mutant H-Ras-C118S, defective for binding PGA1, did not produce cell death. Molecular analysis revealed a key role for the RAF-MEK-ERK signaling pathway in the apoptotic process through the induction of calpain activity and caspase-12 cleavage. We propose that PGA1 evokes a specific physiological cell death program, through H- and N-Ras, but not K-Ras, activation at endomembranes. Our results highlight a novel mechanism that may be of potential interest for tumor treatment. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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