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A Step-By-Step Surgical Protocol for the Treatment of Perianal Fistula with Adipose-Derived Mesenchymal Stem Cells

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APA

Georgiev Hristov, Tihomir & Guadalajara, H. & Herreros, M. D. & Lightner, A. L. & Dozois, E. J. & García Arranz, M. & García-Olmo, D. (2018-07 ) .A Step-By-Step Surgical Protocol for the Treatment of Perianal Fistula with Adipose-Derived Mesenchymal Stem Cells.

ISO 690

Georgiev Hristov, Tihomir & Guadalajara, H. & Herreros, M. D. & Lightner, A. L. & Dozois, E. J. & García Arranz, M. & García-Olmo, D.. 2018-07 .A Step-By-Step Surgical Protocol for the Treatment of Perianal Fistula with Adipose-Derived Mesenchymal Stem Cells.

https://hdl.handle.net/20.500.12080/39598
dc.contributor.author Georgiev Hristov, Tihomir
dc.contributor.author Guadalajara, H.
dc.contributor.author Herreros, M. D.
dc.contributor.author Lightner, A. L.
dc.contributor.author Dozois, E. J.
dc.contributor.author García Arranz, M.
dc.contributor.author García-Olmo, D.
dc.date.accessioned 2024-02-08T14:28:14Z
dc.date.available 2024-02-08T14:28:14Z
dc.date.created 2018-07
dc.date.issued 2018-07
dc.identifier.uri https://hdl.handle.net/20.500.12080/39598
dc.description.abstract Anal fistula is a challenging condition both for surgeons and patients. Recurrent fistula, Crohn¿s disease, or autoimmune disorders add further complexity to this situation. Numerous clinical trials have now demonstrated that cell-based therapy appears to be a good complement to fistulous surgery. As in any new treatment, especially that involving living cells, appropriate application is paramount to achieve optimal outcomes. As stem cell-based treatments are gaining a strong foothold in fistula management worldwide, we herein aim to share our mesenchymal stem cell surgical protocol. With the goal of optimizing results of this emerging therapy, we have improved and refined our protocol over the past 17 years of working with stem cells in clinical trials. The protocol consists of nine reproducible steps for mesenchymal stem cell application inside the fistulous tract, and has proven to be safe and effective in several studies, including international phase III clinical trials. Keywords Mesenchymal stem cells . Perianal fistula . Surgical protocol es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title A Step-By-Step Surgical Protocol for the Treatment of Perianal Fistula with Adipose-Derived Mesenchymal Stem Cells es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/restrictedAccess es_ES
dc.identifier.location N/A es_ES


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