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Activation of bombesin receptor Subtype-3 by [D-Tyr6 ,b Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes

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Moreno Villegas, Zaida & Martín Duce, Antonio & Aparicio, César & Portal Núñez, Sergio & Sanz, Raúl & Mantey, Samuel A. & Jensen, Robert T. & Lorenzo, Oscar & Egido, Jesús & Gonzalez, Nieves (2018-01 ) .Activation of bombesin receptor Subtype-3 by [D-Tyr6 ,b Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes.

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Moreno Villegas, Zaida & Martín Duce, Antonio & Aparicio, César & Portal Núñez, Sergio & Sanz, Raúl & Mantey, Samuel A. & Jensen, Robert T. & Lorenzo, Oscar & Egido, Jesús & Gonzalez, Nieves. 2018-01 .Activation of bombesin receptor Subtype-3 by [D-Tyr6 ,b Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes.

https://hdl.handle.net/20.500.12080/39596
dc.contributor.author Moreno Villegas, Zaida
dc.contributor.author Martín Duce, Antonio
dc.contributor.author Aparicio, César
dc.contributor.author Portal Núñez, Sergio
dc.contributor.author Sanz, Raúl
dc.contributor.author Mantey, Samuel A.
dc.contributor.author Jensen, Robert T.
dc.contributor.author Lorenzo, Oscar
dc.contributor.author Egido, Jesús
dc.contributor.author Gonzalez, Nieves
dc.date.accessioned 2024-02-08T14:11:24Z
dc.date.available 2024-02-08T14:11:24Z
dc.date.created 2018-01
dc.date.issued 2018-01
dc.identifier.uri https://hdl.handle.net/20.500.12080/39596
dc.description.abstract obese and/or diabetic patients, and BRS-3 KO-mice developed obesity. In this work, focused on rat/hu man adipose tissue, BRS-3 gene-expression was lower than normal-levels in hyperlipidemic, type-2- diabetic (T2D), and type-1-diabetic rats and also in obese (OB) and T2D patients. Moreover, BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces; but neither mutation nor even polymorphism in the BRS-3-gene was found in OB or T2D patients. Interestingly, in rat and human adipocytes, without metabolic alterations, [D-Tyr6 ,b-Ala11,Phe13,Nle14]bombesin6-14 dBRS-3- agonistd, as insulin, enhanced BRS-3 gene/protein expression, increased, PKB, p70s6K, MAPKs and p90RSK1 phosphorylation-levels, and induced a concentration-related stimulation of glucose transport, GLUT-4 membrane translocation and lipogenesis, exclusively mediated by BRS-3, and abolished by wortmannin, PD98059 or rapamacyn. These results confirm that BRS-3 and/or its agonist are a potential therapeutic tool for obesity/diabetes. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Activation of bombesin receptor Subtype-3 by [D-Tyr6 ,b Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/restrictedAccess es_ES
dc.identifier.location N/A es_ES


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