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PrognosticValue of LISCH7 mRNA in Plasma and Tumor of Colon Cancer Patients

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APA

García, José M. & Peña, Cristina & García, Vanesa & Domínguez, Gemma & Muñoz, Concepción & Silva, Javier & Milán, Isabel & Díaz, Raquel & Lorenzo, Yolanda & Rodriguez, Rufo & Bonilla, Félix (2007-11 ) .PrognosticValue of LISCH7 mRNA in Plasma and Tumor of Colon Cancer Patients.

ISO 690

García, José M. & Peña, Cristina & García, Vanesa & Domínguez, Gemma & Muñoz, Concepción & Silva, Javier & Milán, Isabel & Díaz, Raquel & Lorenzo, Yolanda & Rodriguez, Rufo & Bonilla, Félix. 2007-11 .PrognosticValue of LISCH7 mRNA in Plasma and Tumor of Colon Cancer Patients.

https://hdl.handle.net/20.500.12080/39574
dc.contributor.author García, José M.
dc.contributor.author Peña, Cristina
dc.contributor.author García, Vanesa
dc.contributor.author Domínguez, Gemma
dc.contributor.author Muñoz, Concepción
dc.contributor.author Silva, Javier
dc.contributor.author Milán, Isabel
dc.contributor.author Díaz, Raquel
dc.contributor.author Lorenzo, Yolanda
dc.contributor.author Rodriguez, Rufo
dc.contributor.author Bonilla, Félix
dc.date.accessioned 2024-02-08T12:10:46Z
dc.date.available 2024-02-08T12:10:46Z
dc.date.created 2007-11
dc.date.issued 2007-11
dc.identifier.uri https://hdl.handle.net/20.500.12080/39574
dc.description.abstract Purpose: LISCH7 is a gene potentially regulated by p53 that is up-regulated in metastasis development. Our hypothesis was that the expression of LISCH7 in primary colorectal tumors determined certain characteristics of the tumors, as well as their behavior, and that its identifi cation in plasma could serve as a prognostic marker. Experimental Design: We tested this hypothesis in a series of 115 tumors and normal tissues and in 83 plasmas from patients with sporadic colorectal carcinomas, as well as in 20 healthy control plasmas in which the expression levels of the gene were measured by real-time PCR. The expression data were contrasted with clinicopathologic variables. Results: Although LISCH7 expression was not detected in any control plasma samples, it was positive in 25 (30.1%) plasmas from patients (P = 0.002 ). LISCH7 mRNA in plasma was signifi cantly associated with the pathologic stage (P = 0.019), with lymph node metastasis (P = 0.008) and with vascular invasion (P = 0.005). Expression was not detected in any normal tissues but was detected in 80 tumor tissues, with a clear association found with vascular invasion (P = 0.027). Moreover, we show that LISCH7 was specifically expressed by the epithelial tumor cells. The adjusted overall survival study showed independent prognostic values for LISCH7 expression levels in tumor tissues (hazard ratio, 3.45; 95% confidence interval, 1.19-9.98). Conclusions: Our results suggest that LISCH7 is a good tumor marker whose expression levels could be considered as a poor prognosis factor in human colon cancer. Furthermore, plasma is suggested as a feasible source of nucleic acids for subsequent noninvasive prognostic studies es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title PrognosticValue of LISCH7 mRNA in Plasma and Tumor of Colon Cancer Patients es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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