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TCL1A expression delineates biological and clinical variability in B-cell lymphoma

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Aggarwal, Mohit & Villuendas, Raquel & Gomez, Gonzalo & Rodriguez Pinilla, Socorro M & Sánchez Beato, Margarita & Alvarez, David & Martinez, Nerea & Rodriguez, Antonia & Castillo, María Encarnación & Camacho, Francisca I & Montes Moreno, Santiago & Garcia Marco, Jose A & Kimby, Eva & Pisano, David G & Piris, Miguel A (2008-09 ) .TCL1A expression delineates biological and clinical variability in B-cell lymphoma.

ISO 690

Aggarwal, Mohit & Villuendas, Raquel & Gomez, Gonzalo & Rodriguez Pinilla, Socorro M & Sánchez Beato, Margarita & Alvarez, David & Martinez, Nerea & Rodriguez, Antonia & Castillo, María Encarnación & Camacho, Francisca I & Montes Moreno, Santiago & Garcia Marco, Jose A & Kimby, Eva & Pisano, David G & Piris, Miguel A. 2008-09 .TCL1A expression delineates biological and clinical variability in B-cell lymphoma.

https://hdl.handle.net/20.500.12080/39548
dc.contributor.author Aggarwal, Mohit
dc.contributor.author Villuendas, Raquel
dc.contributor.author Gomez, Gonzalo
dc.contributor.author Rodriguez Pinilla, Socorro M
dc.contributor.author Sánchez Beato, Margarita
dc.contributor.author Alvarez, David
dc.contributor.author Martinez, Nerea
dc.contributor.author Rodriguez, Antonia
dc.contributor.author Castillo, María Encarnación
dc.contributor.author Camacho, Francisca I
dc.contributor.author Montes Moreno, Santiago
dc.contributor.author Garcia Marco, Jose A
dc.contributor.author Kimby, Eva
dc.contributor.author Pisano, David G
dc.contributor.author Piris, Miguel A
dc.date.accessioned 2024-02-07T14:00:35Z
dc.date.available 2024-02-07T14:00:35Z
dc.date.created 2008-09
dc.date.issued 2008-09
dc.identifier.uri https://hdl.handle.net/20.500.12080/39548
dc.description.abstract The assembly of a collection of gene-expression signatures of the major types of B-cell non-Hodgkin¿s lymphoma has identified increased T-cell leukemia/lymphoma 1A (TCL1) expression in multiple lymphoma types and cases, and has enabled the investigation of the functional and clinical importance of TCL1 expression. Specifically, Burkitt¿s lymphoma cases show a homogeneously strong expression of TCL1, whereas diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia, nodal marginal zone lymphoma, and splenic marginal zone lymphoma display a striking variability in the intensity of TCL1 staining. This was validated in two independent series. A Gene-Set Enrichment Analysis of the genes correlated with TCL1A expression found that variation in the level of expression of TCL1A was significantly associated with some of the most important gene signatures recognizing B-cell lymphoma pathogenesis and heterogeneity, such as germinal center, B-cell receptor, NF-jB (and its target genes), death, MAP kinases, TNFR1, TOLL, and IL1R. Additionally, TCL1 expression was correlated with shorter time to treatment in chronic lymphocytic leukemia cases and shorter lymphoma-specific survival in mantle cell lymphoma series, thus indicating the clinical and biological significance of TCL1 expression, and suggesting TCL1A as a potential therapeutic target es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title TCL1A expression delineates biological and clinical variability in B-cell lymphoma es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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