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EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation

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Montes Moreno, Santiago & Odqvist, Lina & Diaz Perez, Julio A & Batlle Lopez, Ana & Gonzalez de Villambrosí, Sonia & Mazorra, Francisco & Castillo, María Encarnación & López, Mar & Pajares, Raquel & García, Juan F & Mollejo, Manuela & Camacho, Francisca I & Ruiz Marcellán, Carmen & Adrados, Magdalena & Ortiz, Nazario & Franco, Renato & Ortiz Hidalgo, Carlos & Suarez Gauthier, Ana & Young, Ken H & Piris, Miguel A (2012-04 ) .EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation.

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Montes Moreno, Santiago & Odqvist, Lina & Diaz Perez, Julio A & Batlle Lopez, Ana & Gonzalez de Villambrosí, Sonia & Mazorra, Francisco & Castillo, María Encarnación & López, Mar & Pajares, Raquel & García, Juan F & Mollejo, Manuela & Camacho, Francisca I & Ruiz Marcellán, Carmen & Adrados, Magdalena & Ortiz, Nazario & Franco, Renato & Ortiz Hidalgo, Carlos & Suarez Gauthier, Ana & Young, Ken H & Piris, Miguel A. 2012-04 .EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation.

https://hdl.handle.net/20.500.12080/39547
dc.contributor.author Montes Moreno, Santiago
dc.contributor.author Odqvist, Lina
dc.contributor.author Diaz Perez, Julio A
dc.contributor.author Batlle Lopez, Ana
dc.contributor.author Gonzalez de Villambrosí, Sonia
dc.contributor.author Mazorra, Francisco
dc.contributor.author Castillo, María Encarnación
dc.contributor.author López, Mar
dc.contributor.author Pajares, Raquel
dc.contributor.author García, Juan F
dc.contributor.author Mollejo, Manuela
dc.contributor.author Camacho, Francisca I
dc.contributor.author Ruiz Marcellán, Carmen
dc.contributor.author Adrados, Magdalena
dc.contributor.author Ortiz, Nazario
dc.contributor.author Franco, Renato
dc.contributor.author Ortiz Hidalgo, Carlos
dc.contributor.author Suarez Gauthier, Ana
dc.contributor.author Young, Ken H
dc.contributor.author Piris, Miguel A
dc.date.accessioned 2024-02-07T13:53:53Z
dc.date.available 2024-02-07T13:53:53Z
dc.date.created 2012-04
dc.date.issued 2012-04
dc.identifier.uri https://hdl.handle.net/20.500.12080/39547
dc.description.abstract Here, we report a retrospective series of 47 EBV-positive diffuse large B-cell lymphoma associated with advanced age. Histopathology allowed to the identification of different histological patterns: cases with polymorphic diffuse large B-cell lymphoma (29 cases), Hodgkin-like (8 cases) and polymorphic lymphopro liferative disorder-like (9 cases) patterns. One case was purely monomorphic diffuse large B-cell lymphoma. We show that this lymphoma type is a neoplasm with prominent classical and alternative nuclear factor-kB pathway activation in neoplastic cells (79% of the cases showed nuclear staining for p105/p50, 74% for p100/p52 and 63% for both proteins), with higher frequency than that observed in a control series of EBV-negative diffuse large B-cell lymphoma (v2 o0.001). Most cases showed an activated phenotype (95% non-germinal center (Hans algorithm); 78% activated B cell (Choi algorithm)). Clonality testing demonstrated IgH and/or K/Kde/L monoclonal rearrangements in 64% of cases and clonal T-cell populations in 24% of cases. C-MYC (1 case), BCL6 (2 cases) or IgH (3 cases) translocations were detected by FISH in 18% cases. These tumors had a poor overall survival and progression-free survival (the estimated 2-year overall survival was 40±10% and the estimated 2-year progression-free survival was 36±9%). Thus, alternative therapies, based on the tumor biology, need to be tested in patients with EBV-positive diffuse large B-cell lymphoma of the elderly. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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