Lung cancer patients with COVID-19 in Spain: GRAVID study

Provencio, Mariano; Mazarico Gallego, José María; Calles, Antonio; Antoñanzas, Mónica; Pangua, Cristina; Mielgo Rubio, Xabier; Nadal, Ernest; López Castro, Rafael; López Martín, Ana; del Barco, Edel; Dómine, Manuel; Franco, Fernando; Diz, Pilar; Sandoval, Carmen; Sais Girona, Elia; Sullivan, Ivana; Sala, Mª Ángeles; García Ledo, Gema; Cucurull, Marc; Mosquera, Joaquín; Martínez, Mireia; Chara, Luis Enrique; Arriola, Edurne; Esteban Herrera, Beatriz; Jarabo, José Ramón; Álvarez Álvarez, Rosa; Baena, Javier; González Cao, María

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Provencio, Mariano & Mazarico Gallego, José María & Calles, Antonio & Antoñanzas, Mónica & Pangua, Cristina & Mielgo Rubio, Xabier & Nadal, Ernest & López Castro, Rafael & López Martín, Ana & del Barco, Edel & Dómine, Manuel & Franco, Fernando & Diz, Pilar & Sandoval, Carmen & Sais Girona, Elia & Sullivan, Ivana & Sala, Mª Ángeles & García Ledo, Gema & Cucurull, Marc & Mosquera, Joaquín & Martínez, Mireia & Chara, Luis Enrique & Arriola, Edurne & Esteban Herrera, Beatriz & Jarabo, José Ramón & Álvarez Álvarez, Rosa & Baena, Javier & González Cao, María (2021-05 ) .Lung cancer patients with COVID-19 in Spain: GRAVID study.

ISO 690

Provencio, Mariano & Mazarico Gallego, José María & Calles, Antonio & Antoñanzas, Mónica & Pangua, Cristina & Mielgo Rubio, Xabier & Nadal, Ernest & López Castro, Rafael & López Martín, Ana & del Barco, Edel & Dómine, Manuel & Franco, Fernando & Diz, Pilar & Sandoval, Carmen & Sais Girona, Elia & Sullivan, Ivana & Sala, Mª Ángeles & García Ledo, Gema & Cucurull, Marc & Mosquera, Joaquín & Martínez, Mireia & Chara, Luis Enrique & Arriola, Edurne & Esteban Herrera, Beatriz & Jarabo, José Ramón & Álvarez Álvarez, Rosa & Baena, Javier & González Cao, María. 2021-05 .Lung cancer patients with COVID-19 in Spain: GRAVID study.

https://hdl.handle.net/20.500.12080/39500

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Mendeley

dc.contributor.author	Provencio, Mariano
dc.contributor.author	Mazarico Gallego, José María
dc.contributor.author	Calles, Antonio
dc.contributor.author	Antoñanzas, Mónica
dc.contributor.author	Pangua, Cristina
dc.contributor.author	Mielgo Rubio, Xabier
dc.contributor.author	Nadal, Ernest
dc.contributor.author	López Castro, Rafael
dc.contributor.author	López Martín, Ana
dc.contributor.author	del Barco, Edel
dc.contributor.author	Dómine, Manuel
dc.contributor.author	Franco, Fernando
dc.contributor.author	Diz, Pilar
dc.contributor.author	Sandoval, Carmen
dc.contributor.author	Sais Girona, Elia
dc.contributor.author	Sullivan, Ivana
dc.contributor.author	Sala, Mª Ángeles
dc.contributor.author	García Ledo, Gema
dc.contributor.author	Cucurull, Marc
dc.contributor.author	Mosquera, Joaquín
dc.contributor.author	Martínez, Mireia
dc.contributor.author	Chara, Luis Enrique
dc.contributor.author	Arriola, Edurne
dc.contributor.author	Esteban Herrera, Beatriz
dc.contributor.author	Jarabo, José Ramón
dc.contributor.author	Álvarez Álvarez, Rosa
dc.contributor.author	Baena, Javier
dc.contributor.author	González Cao, María
dc.date.accessioned	2024-02-05T09:45:55Z
dc.date.available	2024-02-05T09:45:55Z
dc.date.created	2021-05
dc.date.issued	2021-05
dc.identifier.uri	https://hdl.handle.net/20.500.12080/39500
dc.description.tableofcontents	factors are not yet clearly identified. The GRAVID study aimed to describe clinical characteristics, outcomes, and predictors of poor outcome in patients with lung cancer and COVID-19. Methods: Prospective observational study that included medical records of patients with lung cancer and PCR confirmed COVID-19 diagnosis across 65 Spanish hospitals. The primary endpoint was all-cause mortality; secondary endpoints were hospitalization and admission to intensive care units (ICU). Results: A total of 447 patients with a mean age of 67.1 ± 9.8 years were analysed. The majority were men (74.3 %) and current/former smokers (85.7 %). NSCLC was the most frequent type of cancer (84.5 %), mainly as adenocarcinoma (51.0 %), and stage III metastatic or unresectable disease (79.2 %). Nearly 60 % of patients were receiving anticancer treatment, mostly first-line chemotherapy. Overall, 350 (78.3 %) patients were hospitalized for a mean of 13.4 ± 11.4 days, 9 (2.0 %) were admitted to ICU and 146 (32.7 %) died. Advanced disease and the use of corticosteroids to treat COVID-19 during hospitalization were predictors of mortality. Hospitalized, non end-of-life stage patients with lymphocytopenia and high LDH had an increased risk of death. Severity of COVID 19 correlated to higher mortality, ICU admission, and mechanical ventilation rates. Conclusions: Mortality rate was higher among patients treated with corticosteroids during hospitalization, while anticancer therapy was not associated with an increased risk of hospitalization or death. Tailored approaches are warranted to ensure effective cancer management while minimizing the risk of exposure to SARS-CoV-2.	es_ES
dc.format	application/pdf	es_ES
dc.language	eng	es_ES
dc.rights	CC-BY	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/deed.es	es_ES
dc.title	Lung cancer patients with COVID-19 in Spain: GRAVID study	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.rights.accessrights	info:eu-repo/semantics/openAccess	es_ES
dc.identifier.location	N/A	es_ES