DSpace Repository

Biodistribution Analysis of Oncolytic Adenoviruses in Canine Patient Necropsy Samples Treated with Cellular Virotherapy

Show simple item record

APA

Gómez, Ana & Sardón Ruiz, David & Cejalvo, Teresa & Vázquez, Fernando & García Castro, Javier & Perisé Barrios, Ana Judith (2020-09 ) .Biodistribution Analysis of Oncolytic Adenoviruses in Canine Patient Necropsy Samples Treated with Cellular Virotherapy.

ISO 690

Gómez, Ana & Sardón Ruiz, David & Cejalvo, Teresa & Vázquez, Fernando & García Castro, Javier & Perisé Barrios, Ana Judith. 2020-09 .Biodistribution Analysis of Oncolytic Adenoviruses in Canine Patient Necropsy Samples Treated with Cellular Virotherapy.

https://hdl.handle.net/20.500.12080/39456
dc.contributor.author Gómez, Ana
dc.contributor.author Sardón Ruiz, David
dc.contributor.author Cejalvo, Teresa
dc.contributor.author Vázquez, Fernando
dc.contributor.author García Castro, Javier
dc.contributor.author Perisé Barrios, Ana Judith
dc.date.accessioned 2024-02-01T16:43:28Z
dc.date.available 2024-02-01T16:43:28Z
dc.date.created 2020-09
dc.date.issued 2020-09
dc.identifier.uri https://hdl.handle.net/20.500.12080/39456
dc.description.abstract Oncolytic immunotherapy with competent viruses is an emerging approach in cancer treatment. The clinical safety of many types of oncolytic viruses (OVs) has been demonstrated. However, there is a lack of information about viral bio distribution in patients. The available data about oncolytic adenovirus biodistribution in human subjects treated intrave nously consists of virus detection in body fluids, a few tumor biopsies, and a single report of patient necropsy samples. There is no information about adenoviral biodistribution in patients treated intravenously with cellular vehicles carrying an onco lytic adenovirus. We previously published reports regarding the efficacy and clinical safety of infusing mesenchymal stem cells (MSCs) infected with an OV in human and canine pa tients. In this study, we performed necropsies on 12 canine pa tients treated with dCelyvir, canine MSCs infected with ICO CAV17, a canine oncolytic adenovirus. The prevalence of microscopic lesions, especially chronic inflammatory responses in different organs, was higher than expected. Concomitantly, we found a positive immunoreaction to ICOCAV17 in analyzed samples. These findings support a possible role of the virus in development of histopathological alterations and ongoing systemic viral replication of ICOCAV17 in the period after therapy administration es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Biodistribution Analysis of Oncolytic Adenoviruses in Canine Patient Necropsy Samples Treated with Cellular Virotherapy es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


Files in this item

This item appears in the following Collection(s)

Show simple item record

CC-BY Except where otherwise noted, this item's license is described as CC-BY

Search DSpace


Browse

My Account

Social Media