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Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis

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Ramos, Mónica & Quezada Feijoó, Dolores Maribel & Ayala Muñoz, Rocío & Manzano, Ascensión & Gómez Pavón, Francisco Javier & Jaramillo Hidalgo, Javier & Herrera, Cristina & López Vazquez de la Torre, Mariola & Toro, Rocío (2023-04 ) .Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis.

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Ramos, Mónica & Quezada Feijoó, Dolores Maribel & Ayala Muñoz, Rocío & Manzano, Ascensión & Gómez Pavón, Francisco Javier & Jaramillo Hidalgo, Javier & Herrera, Cristina & López Vazquez de la Torre, Mariola & Toro, Rocío. 2023-04 .Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis.

https://hdl.handle.net/20.500.12080/39442
dc.contributor.author Ramos, Mónica
dc.contributor.author Quezada Feijoó, Dolores Maribel
dc.contributor.author Ayala Muñoz, Rocío
dc.contributor.author Manzano, Ascensión
dc.contributor.author Gómez Pavón, Francisco Javier
dc.contributor.author Jaramillo Hidalgo, Javier
dc.contributor.author Herrera, Cristina
dc.contributor.author López Vazquez de la Torre, Mariola
dc.contributor.author Toro, Rocío
dc.date.accessioned 2024-01-31T13:55:42Z
dc.date.available 2024-01-31T13:55:42Z
dc.date.created 2023-04
dc.date.issued 2023-04
dc.identifier.uri https://hdl.handle.net/20.500.12080/39442
dc.description.abstract Recognizing symptoms in elderly patients with severe aortic stenosis (AS) can be a chal lenge. Serum biomarkers such as Galectin-3 or N-terminal prohormone B-type natriuretic peptide (NT-proBNP) are involved in remodeling and heart failure (HF) development and could support the diagnosis of AS. We set out to test the usefulness of NT-proBNP and Galectin-3 in predicting events in this population. We designed a prospective observational case¿control study, including 50 asymptomatic patients older than 70 years, diagnosed with severe degenerative AS, and 50 con trol individuals. The NT-proBNP and Galectin-3 levels were measured. A follow-up was carried out at 12 months to determine the occurrence of hospital admission for HF, all-cause mortality or the appearance of symptoms. The patients with severe AS had higher Galectin-3 and NT-proBNP concentrations. The area under the receiver operating characteristic curve of the NT-proBNP was 0.812 (95% CI, 0.646¿0.832), and that of the Galectin-3 was 0.633 (95% CI, 0.711¿0.913). NT-proBNP was a good predictor of events [HR 3.45 (95% CI 1.32¿9.03), p = 0.011]. A Kaplan¿Meier analysis showed that the probability of freedom from events was significant in patients who exhibited a combination of higher NT-proBNP and Galectin-3 levels (log-rank p = 0.032). Therefore, NT-proBNP was the most reliable predictor of events in asymptomatic patients with severe AS. A combination of NT-proBNP and Galectin-3 levels may be vital in the clinical follow-up of these patients and in the decision-making process. Keywords: aortic stenosis; older patients; congestive heart failure; Galectin-3; NT-proBNP es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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