APA
Ferrer, Maria D. & Sánchez Barrueco, Álvaro & Martínez Beneyto, Yolanda & Mateos Moreno, María V. & Ausina Márquez, Verónica & García Vázquez, Elisa & Puche Torres, Miguel & Forner Giner, Maria J. & Campos González, Alfonso & Santillán Coello, Jessica Mireya & Alcalá Rueda, Ignacio & Villacampa Auba, José Miguel & Cenjor Español, Carlos & López Velasco, Ana & Santolaya Abad, Diego & García Esteban, Sandra & Artacho, Alejandro & López Labrador, Xavier & Mira, Alex (2021 ) .Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2.
ISO 690
Ferrer, Maria D. & Sánchez Barrueco, Álvaro & Martínez Beneyto, Yolanda & Mateos Moreno, María V. & Ausina Márquez, Verónica & García Vázquez, Elisa & Puche Torres, Miguel & Forner Giner, Maria J. & Campos González, Alfonso & Santillán Coello, Jessica Mireya & Alcalá Rueda, Ignacio & Villacampa Auba, José Miguel & Cenjor Español, Carlos & López Velasco, Ana & Santolaya Abad, Diego & García Esteban, Sandra & Artacho, Alejandro & López Labrador, Xavier & Mira, Alex. 2021 .Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2.
https://hdl.handle.net/20.500.12080/39415
Resumen:
Most public health measures to contain the COVID-19 pandemic are based on preventing the pathogen
spread, and the use of oral antiseptics has been proposed as a strategy to reduce transmission
risk. The aim of this manuscript is to test the efcacy of mouthwashes to reduce salivary viral load
in vivo. This is a multi-centre, blinded, parallel-group, placebo-controlled randomised clinical trial
that tests the efect of four mouthwashes (cetylpyridinium chloride, chlorhexidine, povidone-iodine
and hydrogen peroxide) in SARS-CoV-2 salivary load measured by qPCR at baseline and 30, 60 and
120 min after the mouthrinse. A ffth group of patients used distilled water mouthrinse as a control.
Eighty-four participants were recruited and divided into 12¿15 per group. There were no statistically
signifcant changes in salivary viral load after the use of the diferent mouthwashes. Although oral
antiseptics have shown virucidal efects in vitro, our data show that salivary viral load in COVID-19
patients was not afected by the tested treatments. This could refect that those mouthwashes are
not efective in vivo, or that viral particles are not infective but viral RNA is still detected by PCR. Viral
infectivity studies after the use of mouthwashes are therefore required. (https://clinicaltrials.gov/ct2/
show/NCT04707742; Identifer: NCT04707742