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Chemotactic activities of vasoactive intestinal peptide, neuropeptide Y and substance P in Leishmania braziliensis

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Giammarressi, Michelle & Vanegas, Oriana & Febres, Anthony & Silva-Lopez, Adrian & Ponte-Sucre, Alicia & Díaz López, Emilia (2020 ) .Chemotactic activities of vasoactive intestinal peptide, neuropeptide Y and substance P in Leishmania braziliensis.

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Giammarressi, Michelle & Vanegas, Oriana & Febres, Anthony & Silva-Lopez, Adrian & Ponte-Sucre, Alicia & Díaz López, Emilia. 2020 .Chemotactic activities of vasoactive intestinal peptide, neuropeptide Y and substance P in Leishmania braziliensis.

https://hdl.handle.net/20.500.12080/39377
dc.contributor.author Giammarressi, Michelle
dc.contributor.author Vanegas, Oriana
dc.contributor.author Febres, Anthony
dc.contributor.author Silva-Lopez, Adrian
dc.contributor.author Ponte-Sucre, Alicia
dc.contributor.author Díaz López, Emilia
dc.date.accessioned 2024-01-26T12:17:05Z
dc.date.available 2024-01-26T12:17:05Z
dc.date.created 2020
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12080/39377
dc.description.abstract successful infection by Leishmania. Chemotaxis constitutes a primordial chapter of Leishmania-host cell interaction, potentially modulated by neuropeptides released into the skin due, for example, to the noxious stimuli represented by the insect bite. Herein we have evaluated in vitro the effect of sensory (Substance P, SP) and autonomic (Vasoactive Intestinal Peptide, VIP, and Neuropeptide Y, NPY) neuropeptides on parasite taxis, and investigated the potential modulatory effect of SP on Leishmania (Viannia) braziliensis-macrophage interaction. We demonstrated that VIP (10¿ 10 M) and NPY (10¿ 9 M) are chemorepellent to the parasites, while SP (10¿ 8 M) produces a chemoattractant response. SP did not affect macrophage viability but seems to impair parasitemacrophage interaction as it decreased promastigote adherence to macrophages. As this effect is blocked by ([D-Pro 2, D-Trp7,9]-Substance P (10¿ 6 M), the observed action may be mediated by neurokinin-1 (NK1) transmembrane receptors. VIP and NPY repellent chemotactic effect is impaired by their corresponding receptor antagonists. Additionally, they suggest that SP may be a key molecule to guide promastigote migration towards, and interaction, with dendritic cells and macrophage host cells. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Chemotactic activities of vasoactive intestinal peptide, neuropeptide Y and substance P in Leishmania braziliensis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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