APA
Delgado Bonet, Pablo & Tomeo Martín, Beatriz Davinia & Delgado Bonet, Blanca & Sardón Ruiz, David & Torrado Carvajal, Angel & Mateo, Isidro & Perisé Barrios, Ana Judith .Intracranial Virotherapy for a Canine Hemangioma.
ISO 690
Delgado Bonet, Pablo & Tomeo Martín, Beatriz Davinia & Delgado Bonet, Blanca & Sardón Ruiz, David & Torrado Carvajal, Angel & Mateo, Isidro & Perisé Barrios, Ana Judith. Intracranial Virotherapy for a Canine Hemangioma.
https://hdl.handle.net/20.500.12080/32718
Resumen:
Abstract: Intracranial hemangiomas are rare neoplastic lesions in dogs that usually appear with lifethreatening symptoms. The treatment of choice is tumor resection; however, complete resection is rarely
achieved. The patient¿s prognosis therefore usually worsens due to tumor progression, and adjuvant
treatments are required to control the disease. Oncolytic viruses are an innovative approach that lyses the
tumor cells and induces immune responses. Here, we report the intratumoral inoculation of ICOCAV15
(an oncolytic adenovirus) in a canine intracranial hemangioma, as adjuvant treatment for incomplete
tumor resection. The canine patient showed no side effects, and the tumor volume decreased over the
12 months after the treatment, as measured by magnetic resonance imaging using volumetric criteria.
When progressive disease was detected at month 18, a new dose of ICOCAV15 was administered.
The patient died 31.9 months after the first inoculation of the oncolytic adenovirus. Furthermore,
tumor-infiltrated immune cells increased in number after the viral administrations, suggesting tumor
microenvironment activation. The increased number of infiltrated immune cells, the long survival time
and the absence of side effects suggest that ICOCAV15 could be a safe and effective treatment and
should be further explored as a novel therapy for canine hemangiomas.
Keywords: ICOCAV15; oncolytic adenovirus; virotherapy; immunotherapy; hemangioma; brain
tumor; volumetric criteria