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Lung function, allergic sensitization and asthma in school¿aged children after viral¿coinfection bronchiolitis

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APA

Ruiz, Sara & Calvo, Cristina & Pozo, Francisco & Casas, Inmaculada & García García, María Luz .Lung function, allergic sensitization and asthma in school¿aged children after viral¿coinfection bronchiolitis.

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Ruiz, Sara & Calvo, Cristina & Pozo, Francisco & Casas, Inmaculada & García García, María Luz. Lung function, allergic sensitization and asthma in school¿aged children after viral¿coinfection bronchiolitis.

https://hdl.handle.net/20.500.12080/31866
dc.contributor.author Ruiz, Sara
dc.contributor.author Calvo, Cristina
dc.contributor.author Pozo, Francisco
dc.contributor.author Casas, Inmaculada
dc.contributor.author García García, María Luz
dc.date.accessioned 2022-09-09T08:07:00Z
dc.date.available 2022-09-09T08:07:00Z
dc.date.created 2022
dc.identifier.uri https://hdl.handle.net/20.500.12080/31866
dc.description.abstract Our main objective was to compare the lung function, the rate of allergic sensitization and the prevalence of asthma at 7¿9 years in children hospitalized for bronchiolitis with viral coinfection versus single viral infection. Observational study in children with previous bronchiolitis and current age 7¿9 years. Clinical data were collected. Fraction of exhaled nitric oxide (FeNO) determination, spirometry and skin prick test for common aeroallergens were performed. A total of 181 children hospitalized for bronchiolitis (40 coinfections and 141 single infections), with median age of 8.3 years (IQR:7.5¿9.1) were included. Single-HRV-infections showed lower basal FEV1(%) than coinfections (p = 0.04) and lower z-score FEV1 than single-RSV-infections (p = 0.04) or coinfections (p = 0.02). Also, single-HRV-infections had lower post-bronchodilator FEV1(%) and z-score FEV1 values than coinfections (p = 0.03 and p = 0.03). Single-HRV-bronchiolitis was an independent risk factor for FEV1 < 80% (p = 0.007). FeNO value > 25 ppb was detected in 21(12.5%) cases, without differences between viral groups (p = 0.768). The prevalence of allergic sensitization was similar in coinfections (31.4%) versus single infections (38.7%), (p = 0.428). The highest frequency of allergic rhinitis was observed in single-HRV patients (p = 0.004). The respiratory morbidity at 7¿9 years of coinfected patients was similar to the single-HRV ones. In contrast, the likelihood of current asthma was up to 5 times higher in RSV/HRV coinfections than in the single-RSV-infections ones (p = 0.012). The respiratory morbidity at 7¿9 years of age after severe bronchiolitis is significantly higher in single- HRV or viral coinfection patients that in single-RSV ones. Single-HRV-bronchiolitis is independently associated with lower lung function at school-age. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Lung function, allergic sensitization and asthma in school¿aged children after viral¿coinfection bronchiolitis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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