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https://hdl.handle.net/20.500.12080/31779
dc.contributor.author Contreras Jurado, Silvia Constanza
dc.contributor.author RODRIGUEZ-MUÑOZ, DIEGO
dc.contributor.author Sánchez, Angela
dc.contributor.author PÉREZ-BENAVENTE, SUSANA
dc.contributor.author MONTERO-PEDRAZUELA, ANA
dc.contributor.author TOLEDO-CASTILLO, MARTA
dc.contributor.author GUTIÉRREZ-HERNÁNDEZ, MARÍA
dc.contributor.author RODRIGUES-DÍEZ, RAQUEL
dc.contributor.author FOLGUEIRA, CINTIA
dc.date.accessioned 2022-08-26T14:36:17Z
dc.date.available 2022-08-26T14:36:17Z
dc.date.created 2022-04-06
dc.identifier.uri https://hdl.handle.net/20.500.12080/31779
dc.description.abstract The modulation of the host¿s metabolism to protect tissue from damage induces tolerance to infections increasing survival. Here, we examined the role of the thyroid hormones, key metabolic regulators, in the outcome of malaria. Hypothyroidism confers protection to experimental cerebral malaria by a disease tolerance mechanism. Hypothyroid mice display increased survival after infection with Plasmodium berghei ANKA, diminishing intracranial pressure and brain damage, without altering pathogen burden, blood-brain barrier disruption, or immune cell infiltration. This protection is reversed by treatment with a Sirtuin 1 inhibitor, while treatment of euthyroid mice with a Sirtuin 1 activator induces tolerance and reduces intracranial pressure and lethality. This indicates that thyroid hormones and Sirtuin 1 are previously unknown targets for cerebral malaria treatment, a major killer of children in endemic malaria areas. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.source SCIENCE ADVANCES es_ES
dc.subject Medicina es_ES
dc.subject Hipotiroidismo es_ES
dc.title Hypothyroidism confers tolerance to cerebral malaria es_ES
dc.type info:eu-repo/semantics/acceptedVersion es_ES
dc.description.curso 2022 es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.accrualPolicy Publicación en curso es_ES
dc.identifier.location N/A es_ES


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