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Thyroid hormones act as modulators of inflammation through their nuclear receptors

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https://hdl.handle.net/20.500.12080/31778
dc.contributor.author Contreras Jurado, Silvia Constanza
dc.contributor.author Marina, Lasa
dc.date.accessioned 2022-08-26T14:29:43Z
dc.date.available 2022-08-26T14:29:43Z
dc.date.created 2022-08-08
dc.identifier.uri https://hdl.handle.net/20.500.12080/31778
dc.description.abstract Reciprocal crosstalk between endocrine and immune systems has been well-documented both in physiological and pathological conditions, although the connection between the immune system and thyroid hormones (THs) remains largely unclear. Inflammation and infection are two important processes modulated by the immune system, which have profound effects on both central and peripheral THs metabolism. Conversely, optimal levels of THs are necessary for the maintenance of immune function and response. Although some effects of THs are mediated by their binding to cell membrane integrin receptors, triggering a non-genomic response, most of the actions of these hormones involve their binding to specific nuclear thyroid receptors (TRs), which generate a genomic response by modulating the activity of a great variety of transcription factors. In this special review on THs role in health and disease, we highlight the relevance of these hormones in the molecular mechanisms linked to inflammation upon their binding to specific nuclear receptors. In particular, we focus on THs effects on different signaling pathways involved in the inflammation associated with various infectious and/or pathological processes, emphasizing those mediated by NF-kB, p38MAPK and JAK/STAT. The findings showed in this review suggest new opportunities to improve current therapeutic strategies for the treatment of inflammation associated with several infections and/or diseases, such as cancer, sepsis or Covid-19 infection. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Thyroid hormones act as modulators of inflammation through their nuclear receptors es_ES
dc.type info:eu-repo/semantics/acceptedVersion es_ES
dc.description.curso 2022 es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.accrualPolicy Publicación en curso es_ES
dc.identifier.location N/A es_ES


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