Archivio dell'Università Alfonso X El Sabio

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Mostra i principali dati dell'item

APA

Aguado Garcia, Diana & Olvera, Alex & Brander, Christian & Sanchez Merino, Victor & Yuste, Eloisa .Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope.

ISO 690

Aguado Garcia, Diana & Olvera, Alex & Brander, Christian & Sanchez Merino, Victor & Yuste, Eloisa. Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope.

https://hdl.handle.net/20.500.12080/29442
dc.contributor.author Aguado Garcia, Diana
dc.contributor.author Olvera, Alex
dc.contributor.author Brander, Christian
dc.contributor.author Sanchez Merino, Victor
dc.contributor.author Yuste, Eloisa
dc.date.accessioned 2022-03-22T16:31:07Z
dc.date.available 2022-03-22T16:31:07Z
dc.date.created 2022-03-22
dc.identifier.uri https://hdl.handle.net/20.500.12080/29442
dc.description.abstract The long-term storage stability of vaccines has a major impact on the roll-out and success of global immunization programs. For the Human Immunodeficiency Virus type 1 (HIV-1) virus-like particle (VLP) vaccine prototype evaluated here, nanoparticle tracking analysis (NTA), and enzymelinked immunoabsorbent assay (ELISA) results demonstrated a remarkable structural stability. VLPs maintained their integrity and the recognition of relevant B-cell epitopes for three months at 4 and ¿20 ¿C. Interestingly, most particles remained intact and preserved the recognition of relevant epitopes even after a week of storage at room temperature. Keywords: virus-like particles; HIV; vaccine; thermostability es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


Files in questo item

Questo item appare nelle seguenti collezioni

Mostra i principali dati dell'item

CC-BY Except where otherwise noted, this item's license is described as CC-BY

Cerca in DSpace


Ricerca

My Account

Social Media