Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Aguado Garcia, Diana; Olvera, Alex; Brander, Christian; Sanchez Merino, Victor; Yuste, Eloisa

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APA

Aguado Garcia, Diana & Olvera, Alex & Brander, Christian & Sanchez Merino, Victor & Yuste, Eloisa .Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope.

ISO 690

Aguado Garcia, Diana & Olvera, Alex & Brander, Christian & Sanchez Merino, Victor & Yuste, Eloisa. Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope.

https://hdl.handle.net/20.500.12080/29442

EndNote

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dc.contributor.author	Aguado Garcia, Diana
dc.contributor.author	Olvera, Alex
dc.contributor.author	Brander, Christian
dc.contributor.author	Sanchez Merino, Victor
dc.contributor.author	Yuste, Eloisa
dc.date.accessioned	2022-03-22T16:31:07Z
dc.date.available	2022-03-22T16:31:07Z
dc.date.created	2022-03-22
dc.identifier.uri	https://hdl.handle.net/20.500.12080/29442
dc.description.abstract	The long-term storage stability of vaccines has a major impact on the roll-out and success of global immunization programs. For the Human Immunodeficiency Virus type 1 (HIV-1) virus-like particle (VLP) vaccine prototype evaluated here, nanoparticle tracking analysis (NTA), and enzymelinked immunoabsorbent assay (ELISA) results demonstrated a remarkable structural stability. VLPs maintained their integrity and the recognition of relevant B-cell epitopes for three months at 4 and ¿20 ¿C. Interestingly, most particles remained intact and preserved the recognition of relevant epitopes even after a week of storage at room temperature. Keywords: virus-like particles; HIV; vaccine; thermostability	es_ES
dc.format	application/pdf	es_ES
dc.language	eng	es_ES
dc.rights	CC-BY	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/deed.es	es_ES
dc.title	Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.rights.accessrights	info:eu-repo/semantics/openAccess	es_ES
dc.identifier.location	N/A	es_ES