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Influence of Guided Tissue Regeneration Techniques on the Success Rate of Healing of Surgical Endodontic Treatment: A Systematic Review and Network Meta-Analysis

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Zubizarreta Macho, Álvaro & Tosin, Roberta & Tosin, Fabio & Velasco Bohórquez, Marina del Pilar & San Hipólito Marín, Lara Teresa & Montiel Company, José María & Mena Álvarez, Jesús & Hernández Montero, Sofía .Influence of Guided Tissue Regeneration Techniques on the Success Rate of Healing of Surgical Endodontic Treatment: A Systematic Review and Network Meta-Analysis.

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Zubizarreta Macho, Álvaro & Tosin, Roberta & Tosin, Fabio & Velasco Bohórquez, Marina del Pilar & San Hipólito Marín, Lara Teresa & Montiel Company, José María & Mena Álvarez, Jesús & Hernández Montero, Sofía. Influence of Guided Tissue Regeneration Techniques on the Success Rate of Healing of Surgical Endodontic Treatment: A Systematic Review and Network Meta-Analysis.

https://hdl.handle.net/20.500.12080/29398
dc.contributor.author Zubizarreta Macho, Álvaro
dc.contributor.author Tosin, Roberta
dc.contributor.author Tosin, Fabio
dc.contributor.author Velasco Bohórquez, Marina del Pilar
dc.contributor.author San Hipólito Marín, Lara Teresa
dc.contributor.author Montiel Company, José María
dc.contributor.author Mena Álvarez, Jesús
dc.contributor.author Hernández Montero, Sofía
dc.date.accessioned 2022-03-01T15:42:53Z
dc.date.available 2022-03-01T15:42:53Z
dc.date.created 2022-02-18
dc.identifier.uri https://hdl.handle.net/20.500.12080/29398
dc.description.abstract : Several regeneration techniques and materials have been proposed for the healing of bone defects after surgical endodontic treatment; however, the existing literature does not provide evidence on the most recommended techniques or materials. The aim of the present systematic review and network meta-analysis (NMA) is to summarize the clinical evidence on the efficacy of guided tissue regeneration techniques (GRTs). The PRISMA recommendations were followed. Four databases were searched up to December 2021. Randomized clinical trials (RCTs) with a minimum follow-up of 6 months were included. The risk of bias was assessed using the Cochrane Collaboration tool. A fixed effects model and frequentist approach were used in the NMA. Direct GRT technique comparisons were combined to estimate indirect comparisons, and the estimated effect size of the comparisons was analyzed using the odds ratio (OR). Inconsistency was assessed with the Q test, with a significance level of p < 0.01, and a net heat plot. A total of 274 articles was identified, and 11 RCTs (6 direct comparisons of 15 techniques) were included in the NMA, which examined 6 GRT techniques: control, Os, PL, MB, MB + Os, and MB + PL. The MB + Os group compared to the control (OR = 3.67, 95% CI: 1.36¿9.90) and to the MB group (OR = 3.47, 95% CI: 1.07¿11.3) showed statistically significant ORs (p < 0.05). The MB + Os group presented the highest degree of certainly (P-score = 0.93). Keywords: endodontic surgery; periapical lesion; guided tissue regeneration; bone graft; membrane; platelet rich fibrin es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Influence of Guided Tissue Regeneration Techniques on the Success Rate of Healing of Surgical Endodontic Treatment: A Systematic Review and Network Meta-Analysis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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