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Serum anti-GM2 and anti-GalNAcGD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis

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APA

Mateo Pampliega, Isidro & Halstead, S.K. & Gourlay, D.S & Penderis, J. & Bianchi, E. & Dondi, M. & Wessmann, A. & Musteata, M. & Le Chevoir, M. & Martinez-Anton, L. & Bhatti, S.F.M. & Volk, H. .Serum anti-GM2 and anti-GalNAcGD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis.

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Mateo Pampliega, Isidro & Halstead, S.K. & Gourlay, D.S & Penderis, J. & Bianchi, E. & Dondi, M. & Wessmann, A. & Musteata, M. & Le Chevoir, M. & Martinez-Anton, L. & Bhatti, S.F.M. & Volk, H.. Serum anti-GM2 and anti-GalNAcGD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis.

https://hdl.handle.net/20.500.12080/26318
dc.contributor.author Mateo Pampliega, Isidro
dc.contributor.author Halstead, S.K.
dc.contributor.author Gourlay, D.S
dc.contributor.author Penderis, J.
dc.contributor.author Bianchi, E.
dc.contributor.author Dondi, M.
dc.contributor.author Wessmann, A.
dc.contributor.author Musteata, M.
dc.contributor.author Le Chevoir, M.
dc.contributor.author Martinez-Anton, L.
dc.contributor.author Bhatti, S.F.M.
dc.contributor.author Volk, H.
dc.date.accessioned 2021-11-30T13:50:17Z
dc.date.available 2021-11-30T13:50:17Z
dc.date.created 2021-11
dc.identifier.uri https://hdl.handle.net/20.500.12080/26318
dc.description.abstract Objectives: A previous single-country pilot study indicated serum anti-GM2 and anti-GA1 anti-glycolipid antibodies as potential biomarkers for acute canine polyradiculoneuritis. This study aims to validate these findings in a large geographically heterogenous cohort. Materials and Methods: Sera from 175 dogs clinically diagnosed with acute canine polyradiculoneuritis, 112 dogs with other peripheral nerve, cranial nerve or neuromuscular disorders and 226 neurologically normal dogs were screened for anti-glycolipid antibodies against 11 common glycolipid targets to determine the immunoglobulin G anti-glycolipid antibodies with the highest combined sensitivity and specificity for acute canine polyradiculoneuritis. Results: Anti-GM2 anti-glycolipid antibodies reached the highest combined sensitivity and specificity (sensitivity: 65.1%, 95% confidence interval 57.6 to 72.2%; specificity: 90.2%, 95% confidence interval 83.1 to 95.0%), followed by anti-GalNAc-GD1a anti-glycolipid antibodies (sensitivity: 61.7%, 95% confidence interval 54.1 to 68.9%; specificity: 89.3%, 95% confidence interval 82.0 to 94.3%) and these anti-glycolipid antibodies were frequently present concomitantly. Anti-GA1 anti-glycolipid antibodies were detected in both acute canine polyradiculoneuritis and control animals. Both for anti-GM2 and anti-GalNAc-GD1a anti-glycolipid antibodies, sex was found a significantly associated factor with a female to male odds ratio of 2.55 (P=0.0096) and 3.00 (P=0.0198), respectively. Anti-GalNAc-GD1a anti-glycolipid antibodies were more commonly observed in dogs unable to walk (odds ratio 4.56; P=0.0076). Clinical Significance: Anti-GM2 and anti-GalNAc-GD1a immunoglobulin G anti-glycolipid antibodies represent serum biomarkers for acute canine polyradiculoneuritis. © 2021 The Authors. Journal of Small Animal Practice published by John Wiley & Sons Ltd on behalf of British Small Animal Veterinary Association es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Serum anti-GM2 and anti-GalNAcGD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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