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Effectiveness of Biofunctionalization of Titanium Surfaces with Phosphonic Acid

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APA

Aresti, Ainhoa & Aragoneses, Javier & López Valverde, Nansi & Suárez, Ana & Aragoneses, Juan Manuel .Effectiveness of Biofunctionalization of Titanium Surfaces with Phosphonic Acid.

ISO 690

Aresti, Ainhoa & Aragoneses, Javier & López Valverde, Nansi & Suárez, Ana & Aragoneses, Juan Manuel. Effectiveness of Biofunctionalization of Titanium Surfaces with Phosphonic Acid.

https://hdl.handle.net/20.500.12080/26258
dc.contributor.author Aresti, Ainhoa
dc.contributor.author Aragoneses, Javier
dc.contributor.author López Valverde, Nansi
dc.contributor.author Suárez, Ana
dc.contributor.author Aragoneses, Juan Manuel
dc.date.accessioned 2021-11-30T13:14:17Z
dc.date.available 2021-11-30T13:14:17Z
dc.date.created 2021-11-11
dc.identifier.uri https://hdl.handle.net/20.500.12080/26258
dc.description.abstract : Surface functionalization of dental implant surfaces has been a developing field in biomaterial research. This study aimed to obtain self-assembled monolayers (SAMs) using carboxyethylphosphonic acid on the surface of titanium (Ti) screws, and assessed the surface characteristics, biomechanical, and cellular behavior on the obtained specimens. This study had three groups, i.e., a control (untreated screws), a test group treated with phosphonic acid, and a third group with treated acid and bone morphogenetic protein (BMP-2) for in vitro analysis of cell lines. The assessed parameters included surface wettability, surface characteristics using scanning electron microscopy (SEM), protein immobilization, and cellular behavior of fibroblasts and mesenchymal stem cells of adipose tissue (MSCat cells). For surface wettability, a Welch test was performed to compare the contact angles between control (67 ± 1.83) and test (18.84 ± 0.72) groups, and a difference was observed in the mean measurements, but was not statistically significant. The SEM analysis showed significant surface roughness on the test screws and the cellular behavior of fibroblasts, and MSCat cells were significantly improved in this group, with fibroblasts having a polygonal shape with numerous vesicles and MSCat cells stable and uniformly coating the test Ti surface. Surface biofunctionalization of Ti surfaces with phosphonic acid showed promising results in this study, but remains to be clinically validated for its applications. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.subject surface biofunctionalization; phosphonic acid; surface characteristics; scanning electron microscopy; oral implantology; fibroblasts; stem cells es_ES
dc.title Effectiveness of Biofunctionalization of Titanium Surfaces with Phosphonic Acid es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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