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Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors

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APA

García Serrano, Laura & Contreras Jurado, Silvia Constanza & Martínez Fernández, Mónica & Ruiz Llorente, Lidia & Paramio, Jesus M. & Aranda, Ana .Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors.

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García Serrano, Laura & Contreras Jurado, Silvia Constanza & Martínez Fernández, Mónica & Ruiz Llorente, Lidia & Paramio, Jesus M. & Aranda, Ana. Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors.

https://hdl.handle.net/20.500.12080/26185
dc.contributor.author García Serrano, Laura
dc.contributor.author Contreras Jurado, Silvia Constanza
dc.contributor.author Martínez Fernández, Mónica
dc.contributor.author Ruiz Llorente, Lidia
dc.contributor.author Paramio, Jesus M.
dc.contributor.author Aranda, Ana
dc.date.accessioned 2021-11-10T16:37:04Z
dc.date.available 2021-11-10T16:37:04Z
dc.date.created 2014-09-25
dc.identifier.uri https://hdl.handle.net/20.500.12080/26185
dc.description.abstract Both clinical and experimental observations show that the skin is affected by the thyroidal status. In hypothyroid patients the epidermis is thin and alopecia is common, indicating that thyroidal status might influence not only skin proliferation but also hair growth. We demonstrate here that the thyroid hormone receptors (TRs) mediate these effects of the thyroid hormones on the skin. Mice lacking TRa1 and TRb (the main thyroid hormone binding isoforms) display impaired hair cycling associated to a decrease in follicular hair cell proliferation. This was also observed in hypothyroid mice, indicating the important role of the hormone-bound receptors in hair growth. In contrast, the individual deletion of either TRa1 or TRb did not impair hair cycling, revealing an overlapping or compensatory role of the receptors in follicular cell proliferation. In support of the role of the receptors in hair growth, TRa1/TRb-deficient mice developed alopecia after serial depilation. These mice also presented a wound-healing defect, with retarded re-epithelialization and wound gaping, associated to impaired keratinocyte proliferation. These results reinforce the idea that the thyroid hormone nuclear receptors play an important role on skin homeostasis and suggest that they could be targets for the treatment of cutaneous pathologies es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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