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Eag1 Expression Interferes with Hypoxia Homeostasis and Induces Angiogenesis in Tumors

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APA

Downie, Bryan R. & Sánchez, Araceli & Knötgen, Hendrik & Gymnopoulos, Marco & Contreras Jurado, Silvia Constanza & Weber, Claudia & Stühmer¿, Walter & Pardo, Luis A. .Eag1 Expression Interferes with Hypoxia Homeostasis and Induces Angiogenesis in Tumors.

ISO 690

Downie, Bryan R. & Sánchez, Araceli & Knötgen, Hendrik & Gymnopoulos, Marco & Contreras Jurado, Silvia Constanza & Weber, Claudia & Stühmer¿, Walter & Pardo, Luis A.. Eag1 Expression Interferes with Hypoxia Homeostasis and Induces Angiogenesis in Tumors.

https://hdl.handle.net/20.500.12080/26182
dc.contributor.author Downie, Bryan R.
dc.contributor.author Sánchez, Araceli
dc.contributor.author Knötgen, Hendrik
dc.contributor.author Gymnopoulos, Marco
dc.contributor.author Contreras Jurado, Silvia Constanza
dc.contributor.author Weber, Claudia
dc.contributor.author Stühmer¿, Walter
dc.contributor.author Pardo, Luis A.
dc.date.accessioned 2021-11-10T15:01:15Z
dc.date.available 2021-11-10T15:01:15Z
dc.date.created 2008
dc.identifier.uri https://hdl.handle.net/20.500.12080/26182
dc.description.abstract Ether-a´-go-go-1 (Eag1) is a CNS-localized voltage-gated potassium channel that is found ectopically expressed in a majority of extracranial solid tumors. While circumstantial evi dence linking Eag1 to tumor biology has been well established, the mechanisms by which the channel contributes to tumor pro gression remain elusive. In this study, we have used in vivo and in vitro techniques to identify a candidate mechanism. A muta tion that eliminates ion permeation fails to completely abolish xenograft tumor formation by transfected cells, indicating that Eag1 contributes to tumor progression independently of its pri mary function as an ion channel. Our data suggest that Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Eag1 Expression Interferes with Hypoxia Homeostasis and Induces Angiogenesis in Tumors es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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