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Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity

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Gómez-Varela, David & Zwick Wallasch, Esther & Knótgen, Hendrik & Sánchez, Araceli & Hettmann, Thore & Ossipov, Dmitri & Weseloh, Rüdiger & Contreras Jurado, Silvia Constanza & Rothe, Mike & Stühmer, Walter & Pardo, Luis A. .Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity.

ISO 690

Gómez-Varela, David & Zwick Wallasch, Esther & Knótgen, Hendrik & Sánchez, Araceli & Hettmann, Thore & Ossipov, Dmitri & Weseloh, Rüdiger & Contreras Jurado, Silvia Constanza & Rothe, Mike & Stühmer, Walter & Pardo, Luis A.. Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity.

https://hdl.handle.net/20.500.12080/26181
dc.contributor.author Gómez-Varela, David
dc.contributor.author Zwick Wallasch, Esther
dc.contributor.author Knótgen, Hendrik
dc.contributor.author Sánchez, Araceli
dc.contributor.author Hettmann, Thore
dc.contributor.author Ossipov, Dmitri
dc.contributor.author Weseloh, Rüdiger
dc.contributor.author Contreras Jurado, Silvia Constanza
dc.contributor.author Rothe, Mike
dc.contributor.author Stühmer, Walter
dc.contributor.author Pardo, Luis A.
dc.date.accessioned 2021-11-10T14:50:11Z
dc.date.available 2021-11-10T14:50:11Z
dc.date.created 2007-08
dc.identifier.uri https://hdl.handle.net/20.500.12080/26181
dc.description.abstract The potassium channel ether a` go-go has been directly linked to cellular proliferation and transformation, although its physiologic role(s) are as of yet unknown. The specific blockade of human Eag1 (hEag1) may not only allow the dissection of the role of the channel in distinct physiologic processes, but because of the implication of hEag1 in tumor biology, it may also offer an opportunity for the treatment of cancer. However, members of the potassium channel superfamily are structur ally very similar to one another, and it has been notoriously difficult to obtain specific blockers for any given channel. Here, we describe and validate the first rational design of a monoclonal antibody that selectively inhibits a potassium current in intact cells. Specifically blocking hEag1 function using this antibody inhibits tumor cell growth both in vitro and in vivo. Our data provide a proof of concept that enables the generation of functional antagonistic monoclonal antibodies against ion channels with therapeutic potential. The particular antibody described here, as well as the technique developed to make additional functional antibodies to Eag1, makes it possible to evaluate the potential of the channel as a target for cancer therapy es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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