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Thyroid hormone regulation of APP (b-amyloid precursor protein) gene expression in brain and brain cultured cells

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APA

Contreras Jurado, Silvia Constanza & Pascual, Angel .Thyroid hormone regulation of APP (b-amyloid precursor protein) gene expression in brain and brain cultured cells.

ISO 690

Contreras Jurado, Silvia Constanza & Pascual, Angel .Thyroid hormone regulation of APP (b-amyloid precursor protein) gene expression in brain and brain cultured cells.

https://hdl.handle.net/20.500.12080/26179
dc.contributor.author Contreras Jurado, Silvia Constanza
dc.contributor.author Pascual, Angel
dc.date.accessioned 2021-11-10T14:27:23Z
dc.date.available 2021-11-10T14:27:23Z
dc.date.created 2012-02-13
dc.identifier.uri https://hdl.handle.net/20.500.12080/26179
dc.description.abstract We have previously shown that the thyroid hormone triiodothyronine negatively regulates the transcrip tional activity of the b-amyloid precursor protein gene (APP) in cultured murine neuroblastoma cells, by a mechanism that involves binding of the nuclear thyroid hormone receptor (TR) to DNA sequences located within the first exon of the gene. In this report we present results showing that the thyroid hormones also repress the expression of APP in human neuroblastoma cells and in primary cultures of rat neurons. In addition, and in agreement with the results obtained in cultured cells, APP messenger RNA and protein levels are significantly higher in the brain of hypothyroid rats and mice, and also in Alzheimer-related brain regions dissected from KO mice lacking TRs. These results show that binding of the thyroid hor mones to their nuclear receptors mediate their repressive effect on APP gene expression in vivo es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.subject Amyloid precursor protein ,Thyroid hormone, Hypothyroidism ,TR knockout, Brain es_ES
dc.title Thyroid hormone regulation of APP (b-amyloid precursor protein) gene expression in brain and brain cultured cells es_ES
dc.type info:eu-repo/semantics/book es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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