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APA

Gil Alberdi, Laura & Federico, Concetta & Pinedo, Fernando & Bruno, Francesca & Rebolledo, Ana B. & Montoya, Juan J. & Olazabal Olarreaga, Isabel & Ferrer, Isidre & Saccone, Salvatore .Aging dependent effect of nuclear tau.

ISO 690

Gil Alberdi, Laura & Federico, Concetta & Pinedo, Fernando & Bruno, Francesca & Rebolledo, Ana B. & Montoya, Juan J. & Olazabal Olarreaga, Isabel & Ferrer, Isidre & Saccone, Salvatore. Aging dependent effect of nuclear tau.

https://hdl.handle.net/20.500.12080/25960
dc.contributor.author Gil Alberdi, Laura
dc.contributor.author Federico, Concetta
dc.contributor.author Pinedo, Fernando
dc.contributor.author Bruno, Francesca
dc.contributor.author Rebolledo, Ana B.
dc.contributor.author Montoya, Juan J.
dc.contributor.author Olazabal Olarreaga, Isabel
dc.contributor.author Ferrer, Isidre
dc.contributor.author Saccone, Salvatore
dc.date.accessioned 2021-10-25T13:46:56Z
dc.date.available 2021-10-25T13:46:56Z
dc.date.created 2017
dc.identifier.uri https://hdl.handle.net/20.500.12080/25960
dc.description.abstract Tau protein is characterized by a complex pattern of phosphorylation and is localized in the cytoplasm and nucleus in both neuronal and non-neuronal cells. Human AT100 nuclear tau, endowed by phospho rylation in Thr212/Ser214, was recently shown to decline in cornus ammonis 1 (CA1) and dentate gyrus (DG) in Alzheimer¿s disease (AD), but a defined function for this nuclear tau remains unclear. Here we show that AT100 progressively increases in the nuclei of neuronal and non-neuronal cells during aging, and decreases in the more severe AD stages, as recently shown, and in cancer cells (colorectal adenocar cinoma and breast cancer). AT100, in addition to a co-localization with the DAPI-positive heterochro matin, was detected in the nucleolus of pyramidal cells from the CA1 region, shown to be at its highest level in the more senescent cells and in the first stage of AD (ADI), and disappearing in the more severe AD cases (ADIV). Taking into account the nuclear distribution of AT100 during cell aging and its relation to the chromatin changes observed in degenerated neurons, as well as in cancerous cells, which are both cellular pathologies associated with age, we can consider the Thr212/Ser214 phosphorylated nuclear tau as a molecular marker of cell aging. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.subject Aging ,Nuclear tau, AT100, Alzheimer disease ,Neurons, Epithelial cells ,Colorectal mucosa, Breast acinar cells, Cancer, Confocal microscopy, Aging marker es_ES
dc.title Aging dependent effect of nuclear tau es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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