APA
Niño, Sandra A. & Chi Ahumada, Erika & Rodríguez-Leyva, Ildelfonso & Guerrero, Carmen & Rebolledo, Ana Belén & Arias Navalón, José Antonio & Gil Alberdi, Laura & Jiménez Capdeville, María E. .Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer's Disease Progression.
ISO 690
Niño, Sandra A. & Chi Ahumada, Erika & Rodríguez-Leyva, Ildelfonso & Guerrero, Carmen & Rebolledo, Ana Belén & Arias Navalón, José Antonio & Gil Alberdi, Laura & Jiménez Capdeville, María E.. Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer's Disease Progression.
https://hdl.handle.net/20.500.12080/25959
dc.contributor.author |
Niño, Sandra A. |
|
dc.contributor.author |
Chi Ahumada, Erika |
|
dc.contributor.author |
Rodríguez-Leyva, Ildelfonso |
|
dc.contributor.author |
Guerrero, Carmen |
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dc.contributor.author |
Rebolledo, Ana Belén |
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dc.contributor.author |
Arias Navalón, José Antonio
|
|
dc.contributor.author |
Gil Alberdi, Laura
|
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dc.contributor.author |
Jiménez Capdeville, María E. |
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dc.date.accessioned |
2021-10-25T13:36:49Z |
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dc.date.available |
2021-10-25T13:36:49Z |
|
dc.date.created |
2020-03-07 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12080/25959 |
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dc.description.abstract |
Background. Recent reports point to a nuclear origin of Alzheimer¿s disease (AD).
Aged postmitotic neurons try to repair their damaged DNA by entering the cell cycle. This aberrant
cell cycle re-entry involves chromatin modifications where nuclear Tau and the nuclear lamin are
involved. The purpose of this work was to elucidate their participation in the nuclear pathological
transformation of neurons at early AD. Methodology. The study was performed in hippocampal
paraffin embedded sections of adult, senile, and AD brains at I-VI Braak stages. We analyzed
phospho-Tau, lamins A, B1, B2, and C, nucleophosmin (B23) and the epigenetic marker H4K20me3
by immunohistochemistry. Results. Two neuronal populations were found across AD stages, one is
characterized by a significant increase of Lamin A expression, reinforced perinuclear Lamin B2,
elevated expression of H4K20me3 and nuclear Tau loss, while neurons with nucleoplasmic Lamin B2
constitute a second population. Conclusions. The abnormal cell cycle reentry in early AD implies a
fundamental neuronal transformation. This implies the reorganization of the nucleo-cytoskeleton
through the expression of the highly regulated Lamin A, heterochromatin repression and building
of toxic neuronal tangles. This work demonstrates that nuclear Tau and lamin modifications in
hippocampal neurons are crucial events in age-related neurodegeneration. |
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dc.format |
application/pdf |
es_ES |
dc.language |
eng |
es_ES |
dc.rights |
CC-BY |
es_ES |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/deed.es |
es_ES |
dc.subject |
Alzheimer's disease; Tau protein; Lamin A; Lamin B2; heterochromatin; cell-cycle; hippocampus; neurofibrillary tangles |
es_ES |
dc.title |
Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer's Disease Progression |
es_ES |
dc.type |
info:eu-repo/semantics/article |
es_ES |
dc.rights.accessrights |
info:eu-repo/semantics/openAccess |
es_ES |
dc.identifier.location |
N/A |
es_ES |