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LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later

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Betancor, Diana & Gomez Lopez, Alicia & Villalobos Vilda, Carlos & Nuñez Borque, Emilio & Fernández Bravo, Sergio & De las Heras Gozalo, Manuel & Pastor Vargas, Carlos & Esteban, Vanesa & Cuesta Herranz, Javier .LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later.

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Betancor, Diana & Gomez Lopez, Alicia & Villalobos Vilda, Carlos & Nuñez Borque, Emilio & Fernández Bravo, Sergio & De las Heras Gozalo, Manuel & Pastor Vargas, Carlos & Esteban, Vanesa & Cuesta Herranz, Javier. LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later.

https://hdl.handle.net/20.500.12080/24570
dc.contributor.author Betancor, Diana
dc.contributor.author Gomez Lopez, Alicia
dc.contributor.author Villalobos Vilda, Carlos
dc.contributor.author Nuñez Borque, Emilio
dc.contributor.author Fernández Bravo, Sergio
dc.contributor.author De las Heras Gozalo, Manuel
dc.contributor.author Pastor Vargas, Carlos
dc.contributor.author Esteban, Vanesa
dc.contributor.author Cuesta Herranz, Javier
dc.date.accessioned 2021-06-29T12:28:36Z
dc.date.available 2021-06-29T12:28:36Z
dc.date.created 2021-06-24
dc.identifier.uri https://hdl.handle.net/20.500.12080/24570
dc.description.abstract Introduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high crossreactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis. Methods: One hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods. Results: Ten years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly Rosaceae/Prunoideae fruits and nuts followed by vegetables, Rosacea/Pomoideae fruits, legumes, and cereals. Five out of 38 (13.2%) patients previously sensitized to nsLTP but without allergy to any plant food had experienced allergic reactions to some plant food: two to Rosaceae/Prunoideae fruits, two to Rosaceae/Prunoideae fruit and nuts, and one to legumes. Conclusion: Patients sensitized to nsLTP developed allergic reactions to other plant foods, mainly Rosaceae-Prunoideae fruits and nuts. This was more frequent among plant-food-allergic patients than among those who had never had plant-food allergy. Keywords: nsLTP; plant-food allergy; Pru p 3; peach; nut; Rosaceae fruit; ISAC es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.title LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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