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Machine Learning Study in Caries Markers in Oral Microbiota from Monozygotic Twin Children

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Alía García, Esther & Ponce Alonso, Manuel & Saralegui, Claudia & Halperin, Ana & Paz Cortés, Marta Macarena & Baquero, María Rosario & Parra Pecharroman, David & Galeano, Javier & del Campo, Rosa .Machine Learning Study in Caries Markers in Oral Microbiota from Monozygotic Twin Children.

ISO 690

Alía García, Esther & Ponce Alonso, Manuel & Saralegui, Claudia & Halperin, Ana & Paz Cortés, Marta Macarena & Baquero, María Rosario & Parra Pecharroman, David & Galeano, Javier & del Campo, Rosa. Machine Learning Study in Caries Markers in Oral Microbiota from Monozygotic Twin Children.

https://hdl.handle.net/20.500.12080/24183
dc.contributor.author Alía García, Esther
dc.contributor.author Ponce Alonso, Manuel
dc.contributor.author Saralegui, Claudia
dc.contributor.author Halperin, Ana
dc.contributor.author Paz Cortés, Marta Macarena
dc.contributor.author Baquero, María Rosario
dc.contributor.author Parra Pecharroman, David
dc.contributor.author Galeano, Javier
dc.contributor.author del Campo, Rosa
dc.date.accessioned 2021-05-10T15:19:21Z
dc.date.available 2021-05-10T15:19:21Z
dc.date.created 2021-05
dc.identifier.uri https://hdl.handle.net/20.500.12080/24183
dc.description.abstract : In recent years, the etiology of caries has evolved from a simplistic infectious perspective based on Streptococcus mutans and/or Lactobacillus activity, to a multifactorial disease involving a complex oral microbiota, the human genetic background and the environment. The aim of this work was to identify bacterial markers associated with early caries using massive 16S rDNA. To minimize the other factors, the composition of the oral microbiota of twins in which only one of them had caries was compared with their healthy sibling. Twenty-one monozygotic twin pairs without a previous diagnosis of caries were recruited in the context of their orthodontic treatment and divided into two categories: (1) caries group in which only one of the twins had caries; and (2) control group in which neither of the twins had caries. Each participant contributed a single oral lavage sample in which the bacterial composition was determined by 16S rDNA amplification and further high-throughput sequencing. Data analysis included statistical comparison of alpha and beta diversity, as well as differential taxa abundance between groups. Our results show that twins of the control group have a closer bacterial composition than those from the caries group. However, statistical differences were not detected and we were unable to find any particular bacterial marker by 16S rDNA high-throughput sequencing that could be useful for prevention strategies. Although these results should be validated in a larger population, including children from other places or ethnicities, we conclude that the occurrence of caries is not related to the increase of any particular bacterial population. Keywords: machine learning; oral microbiota; LEfSe; PCoA; alloprevotella; prevotella; core microbiota es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri N/A es_ES
dc.title Machine Learning Study in Caries Markers in Oral Microbiota from Monozygotic Twin Children es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.identifier.location N/A es_ES


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