Archivio dell'Università Alfonso X El Sabio

Aging and Alzheimer´s disease connection: Nuclear Tau and lamin A.

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APA

Gil Alberdi, Laura & Sandra A., Niño & Capdeville, Gabriela & Jiménez Capdeville, María E. .Aging and Alzheimer´s disease connection: Nuclear Tau and lamin A..

ISO 690

Gil Alberdi, Laura & Sandra A., Niño & Capdeville, Gabriela & Jiménez Capdeville, María E.. Aging and Alzheimer´s disease connection: Nuclear Tau and lamin A..

https://hdl.handle.net/20.500.12080/24043
dc.contributor.author Gil Alberdi, Laura
dc.contributor.author Sandra A., Niño
dc.contributor.author Capdeville, Gabriela
dc.contributor.author Jiménez Capdeville, María E.
dc.date.accessioned 2021-02-23T14:49:43Z
dc.date.available 2021-02-23T14:49:43Z
dc.date.created 2021-02-11
dc.identifier.uri https://hdl.handle.net/20.500.12080/24043
dc.description.abstract Age-related pathologies like Alzheimer`s disease (AD) imply cellular responses directed towards repairing DNA damage. Postmitotic neurons show progressive accumulation of oxidized DNA during decades of brain aging, which is especially remarkable in AD brains. The characteristic cytoskeletal pathology of AD neurons is brought about by the progressive changes that neurons undergo throughout aging, and their irreversible nuclear transformation initiates the disease. This review focusses on critical molecular events leading to the loss of plasticity that underlies cognitive deficits in AD. During healthy neuronal aging, nuclear Tau participates in the regulation of the structure and function of the chromatin. The aberrant cell cycle reentry initiated for DNA repair triggers a cascade of events leading to the dysfunctional AD neuron, whereby Tau protein exits the nucleus leading to chromatin disorganization. Lamin A, which is not typically expressed in neurons, appears at the transformation from senile to AD neurons and contributes to halting the consequences of cell cycle reentry and nuclear Tau exit, allowing the survival of the neuron. Nevertheless, this irreversible nuclear transformation alters the nucleic acid and protein synthesis machinery as well as the nuclear lamina and cytoskeleton structures, leading to neurofibrillary tangles formation and final neurodegeneration. es_ES
dc.format application/pdf es_ES
dc.language eng es_ES
dc.rights CC-BY es_ES
dc.rights.uri N/A es_ES
dc.title Aging and Alzheimer´s disease connection: Nuclear Tau and lamin A. es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.rights.accessrights info:eu-repo/semantics/restrictedAccess es_ES
dc.identifier.location N/A es_ES


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