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Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum

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https://hdl.handle.net/20.500.12080/18922
dc.contributor.author Josa-Prado, Fernando
dc.contributor.author Luo, Jia
dc.contributor.author Philip, Rubin
dc.contributor.author Jeremy M., Henley
dc.contributor.author Kevin A., Wilkinson
dc.date.accessioned 2019-02-28T16:40:18Z
dc.date.available 2019-02-28T16:40:18Z
dc.date.created 2019-02
dc.identifier.uri https://hdl.handle.net/20.500.12080/18922
dc.description https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212857 es_ES
dc.description.abstract Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here we monitor the expression of key SUMO pathway proteins and levels of substrate protein SUMOylation in the forebrain and cerebellum of Wistar rats during development. Overall, the SUMOylation machinery is more highly-expressed at E18 and decreases thereafter, as previously described. All of the proteins investigated are less abundant in adult than in embryonic brain. Furthermore, we show for first time that the profiles differ between cerebellum and cerebrum, indicating differential regional regulation of some of the proteins analysed. These data provide further basic observation that may open a new perspective of research about the role of SUMOylation in the development of different brain regions. es_ES
dc.format other es_ES
dc.format.extent 15 es_ES
dc.language eng es_ES
dc.relation.isformatof https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212857 es_ES
dc.rights CC-BY es_ES
dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es es_ES
dc.source Plos One es_ES
dc.title Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum es_ES
dc.type N/A es_ES
dc.rights.accessrights info:eu-repo/semantics/openAccess es_ES
dc.accrualPolicy Publicación en curso es_ES
dc.identifier.location N/A es_ES


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